… of treatment with temozolomide, alone or combined with O(6)-… in vitro: role of O(6)-methylguanine-DNA
methyltransferase and the … Tailored temozolomide therapy according to MGMT …

… We observed that temozolomide treatment induced G 2 -M arrest but that the addition of Δ-24-RGD
was sufficient to override this arrest and resulted in over-representation of the S …

… Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain
tumours (malignant gliomas). The mechanism of TMZ-induced glioma cell death is unknown. …

… progress has been made in its treatment with many clinicians considering glioblastoma …
-care treatment involves maximum safe tumor resection with adjuvant concomitant temozolomide …

We have analyzed the sensitivity of 14 human medulloblastoma- and glioma-derived cell
lines to the clinically used methylating agents temozolomide and streptozotocin. The cell lines …

… and response to treatment with temozolomide in patients with advanced malignant melanoma.
Comparison between pretreatment MGMT levels in peripheral blood mononuclear cells …

… Temozolomide (TMZ) is an alkylating agent that is widely used in chemotherapy for cancer.
… O 6 -methylguanine-DNA methyltransferase (MGMT). MGMT specifically repairs the DNA O 6 …

… O 6 -methylguanine-DNA methyltransferase (MGMT) inactivator lomeguatrib (LM) on patients
with melanoma in two clinical trials. Patients received temozolomide (… before treatment and …

… decreases NF-κB on EMSA (39); however, in this study, only the 48-h temozolomide treatment
time point was evaluated and no analysis of NF-κB–dependent transcription was done. …

… care for newly diagnosed GBM patients includes surgery, radiotherapy and adjuvant
temozolomide (TMZ) treatment, … Direct repair of O6-MeG by the suicide enzyme …