Concomitant treatment of brain metastasis with whole brain radiotherapy [WBRT] and temozolomide [TMZ] is active and improves quality of life

R Addeo, M Caraglia, V Faiola, E Capasso, B Vincenzi… - BMC cancer, 2007 - Springer
… data on the combination of temozolomide with radiation [18]. … treatment combination on
the quality of life of the patients enrolled in the study, overall survival, progression free survival

Glioblastoma management in the temozolomide era: have we improved outcome?

Z Lwin, D MacFadden, A Al-Zahrani, E Atenafu… - Journal of neuro …, 2013 - Springer
Overall survival for all treatment groups are described in Figs.2a, b. For those who received
combined CRT followed by adjuvant TMZ, comparison of our results to EORTC-NCIC CE 3 …

Temozolomide for treatment-resistant recurrent meningioma

MC Chamberlain, DD Tsao-Wei, S Groshen - Neurology, 2004 - AAN Enterprises
survival and overall survival among patients with resistant recurrent meningioma and treated
with temozolomide… disease progression with a median overall survival of 7 months (range 4 …

Temozolomide and unusual indications: review of literature

Z Tatar, E Thivat, E Planchat, P Gimbergues… - Cancer treatment …, 2013 - Elsevier
… , may prolong survival compared to temozolomide alone without radiotherapy (9 … treatments,
some authors have noted disappointing results in term of median overall survival or overall

[PDF][PDF] Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme

SE Combs, S Gutwein, D Schulz-Ertner… - Strahlentherapie und …, 2005 - academia.edu
… and might largely contribute to the prolonged overall survival. Further evaluation is warranted
as to which dose of temozolomide is optimal with regard to tumor response and toxicity. …

Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme

GB Roldán Urgoiti, AD Singh, JC Easaw - Journal of neuro-oncology, 2012 - Springer
… In multivariate analysis, adjuvant monthly Temozolomide for more than six cycles was an …
free—and overall survival. These data suggest extended adjuvant temozolomide (ie, more than …

Multiple resections and survival of recurrent glioblastoma patients in the temozolomide era

A Ortega, JM Sarmiento, D Ly, M Nuño… - Journal of Clinical …, 2016 - Elsevier
… We investigated the relationship between multiple tumor resections and overall survival (OS)
in adult glioblastoma patients who received adjuvant radiotherapy and temozolomide

Molecular mechanisms of temozolomide resistance in glioblastoma multiforme

TCA Johannessen, R Bjerkvig - Expert review of anticancer …, 2012 - Taylor & Francis
… Thus, a growing number of molecular mechanisms contributing to temozolomide resistance
… to temozolomide resistance in robust clinical trials and to ultimately improve overall survival

Effectiveness of temozolomide for primary glioblastoma multiforme in routine clinical practice

JAB Van Genugten, P Leffers, BG Baumert… - Journal of neuro …, 2010 - Springer
overall survival (OS), defined as the time from the starting date of radiotherapy to the date
of death. Secondary endpoints were progression-free survival (PFS), 2-year overall survival

Temozolomide: a milestone in neuro-oncology and beyond?

N Mutter, R Stupp - Expert review of anticancer therapy, 2006 - Taylor & Francis
… Improved progression-free and overall survival was demonstrated for patients treated
with TMZ and RT, but not with RT alone. This effect was absent in patients with a functional (…