… Most risk scores will have been internally validated by using methods such as cross-… or
more) subpopulations, developing the score in 1 group and testing in the other—or bootstrapping. …

… Risk in Communities (ARIC) Study cohort to illustrate how one can choose the optimal set of
SNPs for a genetic risk score (… in GRS for select models that we tested. Results for all models …

… Combining genetic risk factors with clinical risk factors into an integrated risk score is
even more complex, but has been piloted by combining the Gail model risk score, which …

… do not employ test scores simply to report how a test taker … Rather, the scores are used to
support claims that a test taker has… unless the exception applies to the case under consideration…

… Drawing on best practices in clinical genomics, we discuss the unique considerations for
polygenic-based (1) testing, (2) clinical genetic counseling, and (3) translation to population …

… These considerations have led the authors of all current guidelines to stress the need to …
point in the test dataset, and identical risk factor definitions are used in the test and derivation …

“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing
using polygenic risk scores according to healthcare professionals - ScienceDirect Skip to …

… a highly reliable test may produce scores that vary widely … test scores to be stable, but in
the case of mental health tests, a high level of stability would greatly reduce the value of the test…

… This overview reviews the current state of PRS for prostate cancer including testing
considerations. … This study showed that the positive predictive value for PSA testing for …

… principle (assessed via a Nonsense Word Fluency test that measures knowledge of letter-sound …
via an Oral Reading Fluency test). Scores on each DIBELS test are used as predictive …