… We studied the activation of ERK MAP kinase and Akt 1 h after … TGF-α treatment did not
alter ischemia-induced Akt activation, in spite of the fact that signaling through EGFR activates …

… is upregulated by OA chondrocytes, our findings indicate that MEK/ERK activation by TGFα
reduces anabolic activity and thereby the capacity to replace damaged and eroded articular …

… The purpose of this study was to determine if ERK1/2 is activated during the progression
of lung fibrosis in the TGF-α model and identify the cellular distribution. A second goal was to …

… MAPK/ERK cascade was further activated by these mitogens (EGF and TGF-α) in cells
expressing HCV core protein (Fig. 3A). Interestingly, the activation of the MAPK/ERK cascade by …

… shedding, these mechanisms also mediate L‐selectin and TNF‐α cleavage. Thus, L‐… of
Erk MAP kinase or p38 MAP kinase signaling. Our results indicate that activation of Erk and p38 …

… attenuated the additive effect of TGF-α and TNF-α on VEGF production of … TGF-α activates
a network of signaling cascades. Our study demonstrated that TGF-α (250 ng/ml) activated ERK…

… 1 h prior to TGF-β1. To investigate the role of ERK activation in the induction of α-SMA by
TGF-β1, we measured the expression of phosho-ERK1/2 (P-ERK1/2), the activated forms of …

… their activation is generally associated with tyrosine kinase signalling. However, TGF‐β
stimulation also activates Erk … We report that upon TGF‐β stimulation, the activated TGF‐β type I …

… Further investigation indicated that TGF-β activated ERK, which in turn up-regulated MAPK
… ERK and p38 MAPK is dysregulated by simultaneous TGF-β-stimulated ERK activation, …

… -β stimulation, which is comparable to the time course of Erk activation by mitogenic factors
… the delayed activation of Erk by TGF-β, it does not explain the rapid activation of Erk by TGF-β…