HDAC-mediated control of ERK-and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

MJ Barter, L Pybus, GJ Litherland, AD Rowan, IM Clark… - Matrix Biology, 2010 - Elsevier
activation of ERK and PI3K by TGF-β. Collectively, these data confirm that HDACs, and in
particular HDAC3, are required for activation of the ERK and PI3K signalling pathways by TGF-…

Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor β (TGF-β) down-regulation

A Osman, EG Niles, PT LoVerde - Journal of Biological Chemistry, 2004 - ASBMB
… , Erk-mediated phosphorylation of SmSmad4 decreased its interaction with the receptor-activated
through the restoration of TGF-β-responsiveness in MDA-MB-468 breast cancer cells. …

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-β: implications for carcinogenesis

D Javelaud, A Mauviel - Oncogene, 2005 - nature.com
… modulate the outcome of Smad activation by TGF-β, and … of Erk, JNK or p38 MAPK activation
by TGF-β and its biological consequences are not fully characterized. ERK activation by TGF

TGF‐β2 stimulates cranial suture closure through activation of the Erk‐MAPK pathway

SW Lee, KY Choi, JY Cho, SH Jung… - Journal of cellular …, 2006 - Wiley Online Library
… in turn activates Erk through the mediation by protein kinase C. Based on these previous
results, we may not rule out the possibility that TGF-β2-induced cell proliferation, Erk activation

Osteoblasts‐derived TGF‐β1 enhance motility and integrin upregulation through Akt, ERK, and NF‐κB‐dependent pathway in human breast cancer cells

YY Wei, YJ Chen, YC Hsiao, YC Huang… - … in cooperation with …, 2008 - Wiley Online Library
… Taken together, these results suggest that the osteoblast-derived TGF-β1 acts through Akt
and ERK, which in turn activates IKKα/β and NF-κB, resulting in the activations of β1 and β3 …

Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway

Q Zhou, R Zeng, C Xu, L Liu, L Chen, P Kou… - Journal of molecular …, 2012 - Springer
ERK activation was observed in TGF-β1-induced EMT, and Erbin could regulate ERK activation
in response to TGF-… failed to inhibit ERK activation as well as EMT in cells without TGF-β1…

TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways

J Zhang, N Jiang, J Ping, L Xu - … Journal of Molecular …, 2021 - spandidos-publications.com
… inhibitor, PD98059, and JNK inhibitor, SP600125, were able to reverse TGF‑… TGF‑β1‑induced
autophagy is involved in the activation of JS1 cells, possibly through activation of the ERK

Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-β/ERK pathway and epithelial-to …

X Yan, Y Wang, ZF Yu, M Tian, H Li - Life sciences, 2018 - Elsevier
… of PPARγ inhibited these reactions and inhibiting ERK also simulated this … activation in
the diabetic myocardium of mice reduces myocardial fibrosis via regulation of the TGF-β/ERK

Silica-Induced TNF-α and TGF-β1 Expression in RAW264.7 Cells are Dependent on Src-ERK/AP-1 Pathways

X Li, Y Hu, Z Jin, H Jiang, J Wen - Toxicology Mechanisms and …, 2009 - Taylor & Francis
… of ERK and p38 kinase in silica-induced AP-1 activation have … AP-1 activation in macrophages
is mediated by ERK. … induces TNF-α and TGF-β1 expression through the Src-ERK/AP-1 …

[HTML][HTML] TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: an in vivo study

W Xia, CY Cheng - Developmental biology, 2005 - Elsevier
… This suggests that 8 h is a critical time when p-ERK is at best in activating its transcription
factor Elk-1, and at later stage (4–7 days) activated ERK somehow may not contribute much to …