… for altering TGF-β responsiveness during mammary carcinogenesis. Here … of breast cancer
progression and that, when TβRIII expression is restored in human breast cancer cells, breast …

… The transforming growth factor β (TGFβ) growth factors are expressed in most of the tissues
and orchestrate various physiological processes including hormonal and immune responses…

… xenograft model of breast cancer progression to show that loss of TGF-β response is causally
… progression up to the stage of high-grade invasive breast cancer. At this late stage, loss of …

… However, the role of TGF-β in breast cancer progression is ambiguous, as it was shown to
display both tumor-suppressing and -enhancing effects. A polymorphism in the promoter of …

… breast cancer cells, TGF-β signaling in the tumor microenvironment has been shown to prime
cancer … signaling has two distinct and opposite roles in cancer progression and metastasis. …

… roles of TGFβ signalling in carcinomas and their TME, including immune cells, and we
address the expected outcomes of targeting TGFβ signalling in cancer progression to enhance …

… This study provided no evidence of breast cancer risk associations with SNPs in the TGF-β
pathway; however, there may be risks to specific tumour subtypes. The conservation and …

… of mammary epithelial cells and an orthotopic mouse model of breast cancer, we reveal that
Par6 signaling, which is regulated directly by TGFβ, plays a role in breast cancer metastasis. …

… Early loss of TGF-β growth regulation in breast cancer evolves into fundamental … TGF-β
may be important when designing strategies to manage human breast cancer progression…

… breast cancer progression through inhibition of TGF-β … breast cancer progression through
TGF-β signaling-independent and β-arrestin2-dependent activation of Cdc42 to inhibit breast …