… This study reports the identification of Smad3 as a mediator of TGF-~ signaling and demonstrates
that different SMADs (ie Smad3 and Smad4) synergize to achieve high levels of TGF-~ …

… regulators, but also suggested that Smads may be the only required mediators of TGFβ-…
The hypothesis that Smads might be physiological regulators of transcriptional responses was …

… The central role of TGF-β1 as a negative regulator of the immune response, in particular, …
of TGF-β1 in CKD. Indeed, concerns about the potential adverse effects of targeting TGF-β1 has …

… to explain the differential clinical response patterns to anti-PD-1 therapy, the TGF-β pathway
was identified as the key mediator of checkpoint inhibitor resistance [Citation37]. Similarly, …

… a key negative regulator [4,14,15]. Moreover, Smad7 was also found to connect the TGF-β …
the current understanding of Smad7 as both a regulator and a mediator of TGF-β signalling. …

… that overexpression or constitutive activation of negative regulators of TGF-β signaling (ie
I-… of TGF-β and transformation of cells. It will be interesting to determine how these regulatory …

… In addition to these roles in diseasepathogenesis, TGF-β is now established as a principal
mediator of oraltolerance and can be recognized as the sine qua non of a unique subset …

… its role in defining the cell responses to TGF-β. Indeed, the receptor availability and function
… the regulation of receptor function in the context of previous knowledge of TGF-β receptor …

… Transforming growth factor β (TGFβ) pathways are implicated in metazoan development, …
3, TGFβ family transcriptional regulation in development also occurs via the regulation of micro-…

… transduce signals from transforming growth factor-β (TGF-β) … of complexes with the common
mediator Smad (Co-Smad), … facilitating target gene regulation by TGF-β. Smads themselves …