Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function
B Yeganeh, S Mukherjee, LM Moir, K Kumawat… - Pulmonary …, 2013 - Elsevier
… loops that effect ASM phenotype and function. In this … TGF-β signaling, including MAPK,
PI3K, WNT/β-catenin, and Ca 2+ , are discussed, focusing on their effect on ASM phenotype and …
PI3K, WNT/β-catenin, and Ca 2+ , are discussed, focusing on their effect on ASM phenotype and …
TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease
R Sartori, P Gregorevic, M Sandri - Trends in Endocrinology & Metabolism, 2014 - cell.com
… muscle phenotype. This review illustrates how this complex network integrates crosstalk among
members of the TGFβ … Transforming growth factor β inhibits bone morphogenetic protein-…
members of the TGFβ … Transforming growth factor β inhibits bone morphogenetic protein-…
[HTML][HTML] Role of TGF-β signaling in inherited and acquired myopathies
TN Burks, RD Cohn - Skeletal muscle, 2011 - Springer
… Further molecular analyses revealed that an increase in TGF-β signaling was indeed
responsible for the abnormal muscle phenotype and the impaired ability to regenerate muscle in …
responsible for the abnormal muscle phenotype and the impaired ability to regenerate muscle in …
[HTML][HTML] Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation
A Osseni, A Ravel-Chapuis, E Belotti, I Scionti… - Nature …, 2022 - nature.com
… and muscle atrophy. Here, we report that administration of the HDAC6 selective inhibitor
tubastatin A to the Duchenne muscular dystrophy, mdx mouse model increases muscle … muscle …
tubastatin A to the Duchenne muscular dystrophy, mdx mouse model increases muscle … muscle …
[HTML][HTML] Latent TGF-β–binding protein 4 modifies muscular dystrophy in mice
A Heydemann, E Ceco, JE Lim… - The Journal of …, 2009 - Am Soc Clin Investig
… All analyses were conducted in 8-week-old animals, since this time frame corresponds to
an early point in the pathologic process but one at which the muscle phenotype is evident. …
an early point in the pathologic process but one at which the muscle phenotype is evident. …
Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease
… Considering the possibility that persistent, rather than transient, suppression of Smad2/3-activating
ligands was required to improve the dystrophic phenotype in these animals, we …
ligands was required to improve the dystrophic phenotype in these animals, we …
[HTML][HTML] TGF-β in the pathogenesis and prevention of disease: a matter of aneurysmic proportions
HC Dietz - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
… muscle phenotype in γ-sarcoglycan–deficient (Sgcg-deficient) mice, a model of limb girdle
muscular … Remarkably, it was shown that the variation modifying both phenotypes localized to …
muscular … Remarkably, it was shown that the variation modifying both phenotypes localized to …
[HTML][HTML] TGFβ, smooth muscle cells and coronary artery disease: a review
EL Low, AH Baker, AC Bradshaw - Cellular Signalling, 2019 - Elsevier
… vascular cell phenotypes, fibrosis and ECM remodelling. Here we present an overview of TGFβ
… SMC behaviour and phenotype in cardiovascular diseases driven by intimal hyperplasia. …
… SMC behaviour and phenotype in cardiovascular diseases driven by intimal hyperplasia. …
Tuning macrophage phenotype to mitigate skeletal muscle fibrosis
…, S Mascharak, MT Longaker, J Li, B Levi - The Journal of …, 2020 - journals.aai.org
… in TGF-β1 production (11). This study seeks to elucidate the interplay of macrophages and
TGF-β1 in the response to muscle … (IR)–induced muscle fibrosis through more rapid muscle …
TGF-β1 in the response to muscle … (IR)–induced muscle fibrosis through more rapid muscle …
Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β
BCW Groenendijk, GFJD Benus, A Klous… - Experimental cell …, 2011 - Elsevier
… TGF-β and activin A between significantly involved genes in these pathways, we show the
inverse ranking both for TGF-β … expressed in activin A compared to TGF-β treated SMCs at 8 h …
inverse ranking both for TGF-β … expressed in activin A compared to TGF-β treated SMCs at 8 h …
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