… Transforming growth factor β (TGF-β) is part of a larger superfamily of secreted dimeric
multifunctional proteins that also includes activins and bone morphogenetic proteins. It plays an …

… the type I TGF-β receptor kinase, and most known TGF-β inhibitors have several common …
-molecule inhibitors at inhibiting proliferative and immunosuppressive effects of TGF-β in cell…

… of development of each known TGF-β inhibitor will be discussed. As … TGF-β inhibitors, the
known effects of TGF-β deficiency in mice, non-clinical toxicology studies with TGF-β inhibitors …

… The future prospect of new sources and mechanisms of TGF-β inhibitors are discussed in …
rapid and coordinate with triterpenoid-induced TGF-β receptor translocation between lipid rafts/…

… With the purpose of understanding the effect of the inhibition of the TGF-β pathway in GBM,
we decided to identify the gene responses to the TβRI inhibition in patient-derived primary …

… This review discusses the progress made in the pre-clinical and clinical testing of TGFβ
inhibitors, and discusses considerations of target populations and potential drug regimens. …

… Transforming growth factor β (TGFβ) is a member of a large family of secreted growth factors
of … motif determining specific interactions between SMAD proteins and TGF-β receptors. …

… Whereas soluble betaglycan may function as a competitive inhibitor of TGF-β binding to
the cell surface receptors, the membrane-anchored form of betaglycan potentiates …

… the role of TGF- in fibrosis, this chapter will examine the basic rationale for TGF- inhibition
in fibrotic chronic organ remodelling diseases and describe the impact of ALK5 inhibition in …

… Besides mAbs and TGF-β traps, the small molecule inhibitors of TGF-β receptor kinase are
also currently tested in clinical trials combined with immune checkpoint inhibitors. The phase I/…