A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment
… Transforming growth factor β (TGF-β) is part of a larger superfamily of secreted dimeric
multifunctional proteins that also includes activins and bone morphogenetic proteins. It plays an …
multifunctional proteins that also includes activins and bone morphogenetic proteins. It plays an …
Development of TGF-β signalling inhibitors for cancer therapy
JM Yingling, KL Blanchard, JS Sawyer - Nature reviews Drug discovery, 2004 - nature.com
… the type I TGF-β receptor kinase, and most known TGF-β inhibitors have several common …
-molecule inhibitors at inhibiting proliferative and immunosuppressive effects of TGF-β in cell…
-molecule inhibitors at inhibiting proliferative and immunosuppressive effects of TGF-β in cell…
TGF-β inhibitors for the treatment of cancer
M Lahn, S Kloeker, BS Berry - Expert opinion on investigational …, 2005 - Taylor & Francis
… of development of each known TGF-β inhibitor will be discussed. As … TGF-β inhibitors, the
known effects of TGF-β deficiency in mice, non-clinical toxicology studies with TGF-β inhibitors …
known effects of TGF-β deficiency in mice, non-clinical toxicology studies with TGF-β inhibitors …
[HTML][HTML] Recent progress in TGF-β inhibitors for cancer therapy
… The future prospect of new sources and mechanisms of TGF-β inhibitors are discussed in …
rapid and coordinate with triterpenoid-induced TGF-β receptor translocation between lipid rafts/…
rapid and coordinate with triterpenoid-induced TGF-β receptor translocation between lipid rafts/…
TGF-β receptor inhibitors target the CD44high/Id1high glioma-initiating cell population in human glioblastoma
J Anido, A Sáez-Borderías, A Gonzàlez-Juncà… - Cancer cell, 2010 - cell.com
… With the purpose of understanding the effect of the inhibition of the TGF-β pathway in GBM,
we decided to identify the gene responses to the TβRI inhibition in patient-derived primary …
we decided to identify the gene responses to the TβRI inhibition in patient-derived primary …
TGF beta inhibition for cancer therapy
EF Saunier, RJ Akhurst - Current Cancer Drug Targets, 2006 - ingentaconnect.com
… This review discusses the progress made in the pre-clinical and clinical testing of TGFβ
inhibitors, and discusses considerations of target populations and potential drug regimens. …
inhibitors, and discusses considerations of target populations and potential drug regimens. …
The TGFβ receptor activation process: an inhibitor-to substrate-binding switch
… Transforming growth factor β (TGFβ) is a member of a large family of secreted growth factors
of … motif determining specific interactions between SMAD proteins and TGF-β receptors. …
of … motif determining specific interactions between SMAD proteins and TGF-β receptors. …
TGF-β receptor signaling
R Derynck, XH Feng - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1997 - Elsevier
… Whereas soluble betaglycan may function as a competitive inhibitor of TGF-β binding to
the cell surface receptors, the membrane-anchored form of betaglycan potentiates …
the cell surface receptors, the membrane-anchored form of betaglycan potentiates …
TGF-β receptor kinase inhibitors for treatment of fibrosis
NJ Laping, SÉ Huet - Smad signal transduction: Smads in proliferation …, 2006 - Springer
… the role of TGF- in fibrosis, this chapter will examine the basic rationale for TGF- inhibition
in fibrotic chronic organ remodelling diseases and describe the impact of ALK5 inhibition in …
in fibrotic chronic organ remodelling diseases and describe the impact of ALK5 inhibition in …
[HTML][HTML] Recent advances in the development of TGF-β signaling inhibitors for anticancer therapy
HJ Lee - Journal of Cancer Prevention, 2020 - ncbi.nlm.nih.gov
… Besides mAbs and TGF-β traps, the small molecule inhibitors of TGF-β receptor kinase are
also currently tested in clinical trials combined with immune checkpoint inhibitors. The phase I/…
also currently tested in clinical trials combined with immune checkpoint inhibitors. The phase I/…
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