Targeting the TGFβ signalling pathway in disease
RJ Akhurst, A Hata - Nature reviews Drug discovery, 2012 - nature.com
… that target transforming growth factor-β (TGFβ) signalling … TGFβ signalling pathway is a
drug target, the potential clinical applications of TGFβ inhibition, the issues arising with anti-TGFβ …
drug target, the potential clinical applications of TGFβ inhibition, the issues arising with anti-TGFβ …
TGF‐β signalling and liver disease
… that overactivation of TGF-β signalling might contribute to later … For these reasons, targeting
the TGF-β signalling pathway is … -the-art in the signalling pathways induced by TGF-β that are …
the TGF-β signalling pathway is … -the-art in the signalling pathways induced by TGF-β that are …
TGF-β signalling through the Smad pathway
J Massaous, A Hata - Trends in cell biology, 1997 - cell.com
Trans forming growth factor β(TGF-β) and related cytokines regulate cell fate by signalling …
lets us, for the first time, trace a signalling pathway from TGF-β receptors to target genes. …
lets us, for the first time, trace a signalling pathway from TGF-β receptors to target genes. …
[PDF][PDF] TGF beta signalling and its role in tumour pathogenesis.
B Kaminska, A Wesolowska… - Acta Biochimica …, 2005 - bibliotekanauki.pl
… Deregulation of TGFβ expression or signalling has been implicated in the pathogenesis of a
… most common genetic event affecting the TGF-β signalling pathway and occurs in approx. 20…
… most common genetic event affecting the TGF-β signalling pathway and occurs in approx. 20…
TGFβ signalling in context
J Massagué - Nature reviews Molecular cell biology, 2012 - nature.com
… The SMAD signalling pathway is a central 'conduit' for all these gene responses and, as such,
it … The context more than the proteins involved in the signalling pathway is what shapes the …
it … The context more than the proteins involved in the signalling pathway is what shapes the …
TGF-β receptors and signalling mechanisms
JL Wrana - Mineral and electrolyte metabolism, 1998 - karger.com
… The regulation of Smad1 and Smad2 phosphorylation by BMP and TGF-ß/activin signalling
pathways, respectively, is thightly regulated. Recent studies have revealed that MADR …
pathways, respectively, is thightly regulated. Recent studies have revealed that MADR …
Integration of the TGF-β pathway into the cellular signalling network
M Lutz, P Knaus - Cellular signalling, 2002 - Elsevier
… within the signalling network are currently in the centre of TGF-β signal transduction research
and … The two parallel signalling pathways of TGF-β1 in endothelial cells, mediated by either …
and … The two parallel signalling pathways of TGF-β1 in endothelial cells, mediated by either …
TGF-β signalling and its role in cancer progression and metastasis
Y Drabsch, P Ten Dijke - Cancer and Metastasis Reviews, 2012 - Springer
… This review discusses the TGF-β signalling pathway, its … TGF-β signalling is also essential
for embryonic development, … Alterations of the TGF-β signalling pathway are involved in human …
for embryonic development, … Alterations of the TGF-β signalling pathway are involved in human …
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
… and Smad2 act together in activin and TGF-B signalling pathways in breast epithelial cells. …
in distinct TGF-ß signalling pathways (Fig. 5). The entire SMAD signalling network may …
in distinct TGF-ß signalling pathways (Fig. 5). The entire SMAD signalling network may …
[HTML][HTML] TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
… Among the large number of signaling molecules, the transforming growth factor β (TGF-β)
family is highly conserved in the animal kingdom, and is thought to have appeared from the …
family is highly conserved in the animal kingdom, and is thought to have appeared from the …
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