… of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5) … The TGF-β type I receptor
in turn phosphorylates Smad2 and … of ALK5 phosphorylation of Smad3 will reduce TGF-β1 …

… In the present study we show that the Tgf-β type I receptor Alk5 is required for normal EMT
in mice. This finding is consistent with a recent report from the Runyan laboratory, which …

… , TGF-β1 signals potently and passes the activation threshold to evoke NMuMG cell
transdifferentiation. The TGF-β type I receptor (ALK-5) … dose of CA-ALK-5 receptor that cannot lead …

… the type I TGF receptor (ALK5 kinase) or in one instance, a dual ALK5/TGFRII kinase inhibitor
[13, 14]. ALK5 is a receptor in the TGF superfamily of receptors [15]. Type I receptors in this …

… ALK5 mediates a TGFβ-dependent recruitment of ALK1 into a TGFβ receptor complex and
that the ALK5 … the activation state of the endothelium via two distinct TGF β type I receptors. …

… Our results also suggest that an active TGF-β response mediated by the ALK5 receptor is
required for ET-1 to exert its effect, suggesting that ET-1 is acting in conjunction with other …

… or are stimulated with TGF-β and identify genes that are differentially expressed as a response
to TGF-β signaling. Our results create a data set of 465 targets of TGF-β/Alk5 signaling, in …

… In this report, we have analyzed the role of TGFβ1 and its two type I receptors, ALK1 and
ALK5, in vascular development using an in vitro model of embryonic stem cell (ESC) …

… TGF-β requires the kinase activity and the L45 loop motif of the type I TGF-β receptor, ALK5
to … In conclusion, although TβRI ALK5 transduces the main TGF-β signals through Smad3 to …

… Transforming Growth Factor β (TGFβ) is crucial for inducing chondrogenic differentiation
of … to activate ALK5 as well as ALK1 receptors, our aim was to elucidate whether ALK5 and …