… effects of TGF-β3 on cartilage regeneration. Results/conclusion: There is robust in vitro evidence
suggesting a positive dose- and time-dependant effect of TGF-β3 … TGF-β3 cultured with …

… TGF-β3 for organogenesis with engineering methodology and a regenerative medical
perspective. Results/conclusion: TGF-β3 … broad and important effects of TGF-β3 on organogenesis…

… the molecular mechanisms and efficacy of scar reduction therapies between these species.
We … to evaluate the safety and efficacy of human recombinant TGFβ3 (JuvistaTM) in human …

… that TGF-β 3 might function as a gatekeeper controlling downstream signaling despite high
expression of TGF-β 1 and TGF-β … the inhibitory effect on SMAD phosphorylation by TGF-β 3 -…

… transforming growth factor βs (TGF-βs), TGF-β1, -β2, and -β3, … , treatment of chronic fibrotic
conditions by current anti-TGF-β … a therapeutic window and dosing regimen between efficacy …

… Indeed pre-clinical data showing the suppressor effects of TGF-β3 in the early stages of
tumourigenesis, coupled with the acute, low doses applied and the low systemic bioavailability …

… One subject discontinued because of an unsatisfactory therapeutic effect and another
discontinued because of aspiration pneumonia. Despite these dropouts, all 14 patients were in the …

… We further investigated the effects of TGF-β1, TGF-β2, and TGF-β3 on the epithelial markers,
E-cadherin and occludin, and the mesenchymal markers, vimentin and N-cadherin, by …

… Taken together, the direct effects of TGF-β on tumour cells and its indirect effects on tumour
… In humans, three distinct isoforms of TGF-β (TGF-β1, -β2 and -β3) have been identified, all …

… treatment, and provide perspectives of combined treatment to overcome chemo/targeted/radio-therapy
resistance and increase the efficiency … and after treatment with 5 ng/ml TGFβ3 for …