… dysregulated immune response during sepsis and plays a very … during sepsis to design
future target-based therapeutics … sepsis and its targeting as a future therapeutic approach. …

… and the shortcomings of contemporary approaches to clinical research are increasingly …
focus of this manuscript, however, is novel therapies that target putative mediators of sepsis. …

… This article reviews key elements of sepsis management, focusing on diagnosis, biomarkers
and therapy. The main … This means that a personalized therapeutic approach is necessary. …

… to novel therapeutic approaches in the treatment of septic patients. Although many of these
approaches have failed, recent studies have demonstrated the benefit of EGDT in sepsis and …

… by removing the molecular infectious stimulus of sepsis, and (2) … and therapeutics and their
role in the management of sepsis. … inflammation to develop therapeutic approaches to sepsis. …

… developing novel therapeutic approaches that interfere with specific mediators in sepsis. While
it … of the pathogenesis of sepsis and to develop specific therapeutics for severe sepsis, the …

… , and knowledge of which dysregulated biological organ system or pathway drives sepsis-…
therapies. Here, we discuss the drawbacks of previous attempts to develop sepsis therapeutics …

… The main focus of this review is on immune-modulating therapies (ie, vertical approach).
We also discuss other potential therapeutic targets in sepsis (horizontal approach – eg, iron …

… therefore could benefit from adjunctive immune stimulating therapies. There is thus an urgent
… approach in the design of clinical trials evaluating immunostimulating therapies in sepsis at …

… Restoration of tissue perfusion and optimization of hemodynamic status are important goals
of supportive therapy in sepsis and septic shock. Fluid therapy and vasopressor infusion are …