Mechanisms and treatment of organ failure in sepsis

C Lelubre, JL Vincent - Nature Reviews Nephrology, 2018 - nature.com
… might influence therapeutic approaches for the treatment of patients with sepsis. … Another
therapeutic approach in the treatment of sepsis is to protect individual organs. For example, the …

Therapeutic approaches to reduce systemic inflammation in septic-associated neurologic complications

ML Wratten - European Journal of Anaesthesiology, 2008 - cambridge.org
… Acute Therapies, Mirandola (MO), Italy Summary Treatment of severe sepsis and septic shock
… Neurologic complications, such as sepsis-associated encephalopathy, frequently occur in …

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges

Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
… of multiple organ dysfunction in sepsis. We will also introduce a number of fascinating
therapeutic approaches to prevent the development of sepsis organ failure that have received …

Immunomodulatory therapies in sepsis

WJ Kox, T Volk, SN Kox, HD Volk - Intensive care medicine, 2000 - Springer
… in the pathogenesis of sepsis and septic shock. In addition, patients with sepsis also undergo
… immunological monitoring during the course of sepsis. We have recently demonstrated that …

CytoSorb, a novel therapeutic approach for patients with septic shock: a case report

B Hinz, O Jauch, T Noky, S Friesecke, P Abel, R Kaiser - 2015 - journals.sagepub.com
… has gained attention as a potential immunotherapy to control systemic inflammation and
sepsis. We report on a patient with septic shock, successfully treated with CytoSorb therapy. …

Sepsis: current definition, pathophysiology, diagnosis, and management

AM Taeb, MH Hooper, PE Marik - Nutrition in Clinical Practice, 2017 - Wiley Online Library
… with novel therapeutic approaches promises to … therapies to directly alter the pathophysiology
of sepsis, we must focus much of our care on the multidisciplinary support of the septic

Appraisal of four novel approaches to the prevention and treatment of sepsis

A Kumar, HJ Mann - American journal of health-system …, 2004 - academic.oup.com
… It is therefore remarkable that the past few years have witnessed the reporting of four
novel therapeutic approaches—drotrecogin alfa (activated), tight glycemic control, early goal-…

Getting sepsis therapy right

RS Hotchkiss, ER Sherwood - Science, 2015 - science.org
… in septic patients and elevated blood IL-3 concentrations. … ) into a mouse model of sepsis led
to reprogramming of immune … cell–based therapy represent potential approaches for sepsis

Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response

DS Wheeler, B Zingarelli, WJ Wheeler… - Recent patents on …, 2009 - ingentaconnect.com
… Further studies will be required to establish both the safety and efficacy of this therapeutic
approach in critically ill patients with severe sepsis and septic shock. To this end, a phase III, …

[PDF][PDF] Sepsis: Menu of new approaches replaces one therapy for all

SP Larosa - Cleveland Clinic journal of medicine, 2002 - cdn.mdedge.com
sepsis, after a long string of disappointments. Although improved understanding of the
pathophysiology of sepsis … of a “one therapy for all” approach, we are finding that therapy directed …