… of methods to limit NF-κB signaling for pharmacological intervention. This article describes
some of the approaches that have been employed to inhibit NF-κB … use of NF-κB inhibitors are …

… the NF-κB signaling pathway for many therapeutic applications. However, a gene knock-out
study for IKKβ in the NF-κB … associated with efficacy as therapeutics. Mice lacking hepatocyte …

… Targeting NF-κB may be a novel and important preventive or therapeutic strategy against
human cancers and chronic diseases that are caused in part due to induction of oxidative stress…

… IKK/NF-κB signaling pathways. The classical pathway is activated by a variety of inflammatory
signals, resulting in coordinate expression of multiple inflammatory and innate immune …

… and data derived from genetic studies in humans that provide an insight into potential effects
of different therapeutic modulations of NF-κB inflammatory signaling. The pros and cons of …

… Thus, inhibiting NF-κB signaling has potential therapeutic application in cancer and … the
signaling mechanisms and biological functions of the NF-κB pathway, and the role of NF-κB in …

… and cons of blocking NF-κB as a therapeutic approach for inflammatory bowel … approaches
to inhibit NF-κB activity, we suggest that there are certain niche indications for blocking NF-κB …

… to design better and more efficient therapeutic approaches to treat complex diseases like …
NFκB in cancer, and then focus on the approaches that are being undertaken to develop NFκB …

… Given NF-κB's relevance in human diseases and the fact that many drugs interfere … NF-κB
signaling, the NF-κB signaling pathway provides a highly attractive target for the therapeutic …

… Abnormal activation of signaling pathways is involved … therapies against effectors in oncogenic
signaling have improved the outcomes of cancer patients. NFκB is an important signaling …