… Finally, we offer some perspectives on future challenges to developing therapies that are
based on this important drug target. This report should serve as a knowledge base for chemical …

… In the following sections, we will review disease specific studies involving Nrf2 activation/overexpression
as a therapeutic strategy to modulate the progression of major …

… The important role of Nrf2 in protecting against the onset of specific diseases and drug-…
the emerging role of Nrf2 in promoting oncogenesis and chemotherapeutic drug resistance. A …

… zipper (bZip) transcription factor Nrf2 (nuclear factor E2-… depends on the nuclear translocation
of Nrf2 and its binding to the so… the Nrf2ARE signalling pathway is an attractive therapeutic …

… , NRF2/KEAP1 signaling pathway … NRF2 signaling pathway focusing on its cancer-related
functions. We further explore activators and inhibitors of this pathway as cancer targeting drug …

… For this reason, BACH1 may represent a promising target of drug development in order to
activate the Nrf2 pathway [86]. Interestingly, several studies used synthetic small molecules to …

… A549 cells to therapeutic drugs. Thus, luteolin is a promising dietary agent for inhibiting
Nrf2 and may be useful for targeting Nrf2 in therapy to sensitize cancer to therapeutic drugs. …

… drugs. Li and co-workers [93] found that Res ameliorated the resistance to adriamycin (a
chemotherapy drug) through regulation of the PI3K/Akt/Nrf2 … in pancreatic cancer therapy. In the …

… Nrf2 signaling and the inflammation as well as possible approaches for the therapeutic
modulation of this pathway. … for developing a candidate drug in the Nrf2 pathway would be the …

… Dimethyl Fumarate is the only Food and Drug Administration—and European Medicines
Agency—approved drug registered as an Nrf2 activator. Sulforaphane is an isothiocyanate …