Patient subsets and variation in therapeutic efficacy.

R Simon - British Journal of Clinical Pharmacology, 1982 - Wiley Online Library
… separate analyses of relative treatment efficacy within patient subsets can be illustrated as
… B and partition our patients into G mutually exclusive subsets. For each subset we perform a …

Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes

AJ Coles, E Fox, A Vladic, SK Gazda, V Brinar… - The Lancet …, 2011 - thelancet.com
therapy after three patients developed immune thrombocytopenia, one of whom died. During
the suspension, all safety and efficacy assessments proceeded as planned, and patients

Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program.

C Jacobs, R Makuch - Journal of Clinical Oncology, 1990 - ascopubs.org
… Since head and neck cancer patients are a heterogeneous group, there may be particular
sites and stages for which adjuvant chemotherapy would be advantageous, and subset

Efficacy and safety in older patient subsets in studies of endocrine monotherapy versus combination therapy in patients with HR+/HER2− advanced breast cancer: a …

RA Freedman, SM Tolaney - Breast cancer research and treatment, 2018 - Springer
… Although it is reassuring that the benefits of combination therapypatient subsets may not
be fully representative of older breast cancer patients in the general population, as patients with …

The design of clinical studies to assess therapeutic efficacy in multiple sclerosis

JR Brown, GW Beebe, JF Kurtzke, RB Loewenson… - Neurology, 1979 - AAN Enterprises
… trials of therapy for multiple … therapy fails to show any therapeutic effect. The diagnosis,
clinical course, and definitions of the stages of MS are discussed as they relate to trials of therapy. …

Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy

PY Wen, J Drappatz, J De Groot, MD Prados… - Neuro …, 2018 - academic.oup.com
efficacy and safety of 2 doses of cabozantinib in 222 patientssubset of patients who were
naive to antiangiogenic therapy at … for patients who received prior antiangiogenic therapy are …

Considerations for developing targeted therapies in low‐frequency molecular subsets of a disease

RN Schuck, J Woodcock, I Zineh, P Stein… - … & Therapeutics, 2018 - Wiley Online Library
… Targeted therapies are drugs that, based on their mechanism of action, are designed to …
subsets of patients with specific molecular alterations among the larger population of patients

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
… In recent years, enormous effort has been made in the assessment of the prognostic
value of multiple immune cell subsets. Herein, we provide a comprehensive summary of the …

[HTML][HTML] Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib …

AL Cheng, Z Guan, Z Chen, CJ Tsao, S Qin… - European Journal of …, 2012 - Elsevier
… with HCC, our findings indicate that sorafenib simplifies the process for initiating therapy
and minimises or eliminates some of the clinical parameters that may be contraindications to …

[HTML][HTML] Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial

J Bruix, JL Raoul, M Sherman, V Mazzaferro… - Journal of …, 2012 - Elsevier
… Results are limited by small patient numbers in some subsets. … of patients who had received
prior curative therapies or TACE … a trend toward improved OS, irrespective of prior therapy. …