Patient subsets and variation in therapeutic efficacy.
R Simon - British Journal of Clinical Pharmacology, 1982 - Wiley Online Library
… separate analyses of relative treatment efficacy within patient subsets can be illustrated as
… B and partition our patients into G mutually exclusive subsets. For each subset we perform a …
… B and partition our patients into G mutually exclusive subsets. For each subset we perform a …
Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes
AJ Coles, E Fox, A Vladic, SK Gazda, V Brinar… - The Lancet …, 2011 - thelancet.com
… therapy after three patients developed immune thrombocytopenia, one of whom died. During
the suspension, all safety and efficacy assessments proceeded as planned, and patients …
the suspension, all safety and efficacy assessments proceeded as planned, and patients …
Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program.
C Jacobs, R Makuch - Journal of Clinical Oncology, 1990 - ascopubs.org
… Since head and neck cancer patients are a heterogeneous group, there may be particular
sites and stages for which adjuvant chemotherapy would be advantageous, and subset …
sites and stages for which adjuvant chemotherapy would be advantageous, and subset …
Efficacy and safety in older patient subsets in studies of endocrine monotherapy versus combination therapy in patients with HR+/HER2− advanced breast cancer: a …
RA Freedman, SM Tolaney - Breast cancer research and treatment, 2018 - Springer
… Although it is reassuring that the benefits of combination therapy … patient subsets may not
be fully representative of older breast cancer patients in the general population, as patients with …
be fully representative of older breast cancer patients in the general population, as patients with …
The design of clinical studies to assess therapeutic efficacy in multiple sclerosis
JR Brown, GW Beebe, JF Kurtzke, RB Loewenson… - Neurology, 1979 - AAN Enterprises
… trials of therapy for multiple … therapy fails to show any therapeutic effect. The diagnosis,
clinical course, and definitions of the stages of MS are discussed as they relate to trials of therapy. …
clinical course, and definitions of the stages of MS are discussed as they relate to trials of therapy. …
Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy
… efficacy and safety of 2 doses of cabozantinib in 222 patients … subset of patients who were
naive to antiangiogenic therapy at … for patients who received prior antiangiogenic therapy are …
naive to antiangiogenic therapy at … for patients who received prior antiangiogenic therapy are …
Considerations for developing targeted therapies in low‐frequency molecular subsets of a disease
RN Schuck, J Woodcock, I Zineh, P Stein… - … & Therapeutics, 2018 - Wiley Online Library
… Targeted therapies are drugs that, based on their mechanism of action, are designed to …
subsets of patients with specific molecular alterations among the larger population of patients …
subsets of patients with specific molecular alterations among the larger population of patients …
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
… In recent years, enormous effort has been made in the assessment of the prognostic
value of multiple immune cell subsets. Herein, we provide a comprehensive summary of the …
value of multiple immune cell subsets. Herein, we provide a comprehensive summary of the …
[HTML][HTML] Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib …
AL Cheng, Z Guan, Z Chen, CJ Tsao, S Qin… - European Journal of …, 2012 - Elsevier
… with HCC, our findings indicate that sorafenib simplifies the process for initiating therapy
and minimises or eliminates some of the clinical parameters that may be contraindications to …
and minimises or eliminates some of the clinical parameters that may be contraindications to …
[HTML][HTML] Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial
… Results are limited by small patient numbers in some subsets. … of patients who had received
prior curative therapies or TACE … a trend toward improved OS, irrespective of prior therapy. …
prior curative therapies or TACE … a trend toward improved OS, irrespective of prior therapy. …
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