The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review

X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
… from apoptosis. A growing number of studies have investigated pyroptosis and its relationship
with … targets of pyroptosis have been highlighted to explore their therapeutic effect and …

Apoptosis and caspases regulate death and inflammation in sepsis

RS Hotchkiss, DW Nicholson - Nature Reviews Immunology, 2006 - nature.com
… It is possible however that the most effective therapy of sepsis might lie in targeting anti-apoptotic
therapy to specific cell populations. For example, it might be advantageous to …

Therapeutic potential of extracellular vesicles for sepsis treatment

SM Kronstadt, AE Pottash, D Levy, S Wang… - … therapeutics, 2021 - Wiley Online Library
… , anti-apoptotic, and immunomodulatory effects in sepsis models. The dual nature of EVs
in … One such new direction has been the exploration of cell-based therapeutics. Cell …

Role of apoptotic cell death in sepsis

RS Hotchkiss, KW Tinsley, IE Karl - Scandinavian journal of …, 2003 - Taylor & Francis
… This new understanding of sepsis may lead to novel therapeutic approaches including …
Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 2001; 15: 879Á/92. …

Therapeutic potential of annexins in sepsis and COVID-19

L Mui, CM Martin, BJ Tschirhart, Q Feng - Frontiers in Pharmacology, 2021 - frontiersin.org
… to apoptosis, are promising therapeutic agents to reduce the severity of inflammatory
processes in COVID-19. However, the exact mechanism of COVID-19 coagulopathy is not fully …

The potential immunological mechanisms of sepsis

X Zhang, Y Zhang, S Yuan, J Zhang - Frontiers in Immunology, 2024 - frontiersin.org
… of sepsis. We also try to explore the future direction of sepsis diagnosis and therapy in …
Inhibition of lymphocyte apoptosis has been demonstrated to lower sepsis mortality (70). …

Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential

L Xl, Z Gy, CN - Frontiers in Immunology, 2022 - frontiersin.org
… non-apoptotic cell … sepsis can be confirmed and whether the exploration of ferroptosis as
a direction of intervention can bring a breakthrough in the treatment and management of sepsis

Apoptosis-induced lymphopenia in sepsis and other severe injuries

T Girardot, T Rimmelé, F Venet, G Monneret - Apoptosis, 2017 - Springer
Therapies modulating apoptosis represent an interesting approach to restore immune
competence … process in physiology and during severe injuries, we will explore the immunological …

Revisiting caspases in sepsis

M Aziz, A Jacob, P Wang - Cell death & disease, 2014 - nature.com
… of apoptosis and inflammation, and their striking roles in sepsis … Further studies to explore
the mechanism by which cytosolic … delineating sepsis pathobiology and novel therapeutics

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
… to abnormal lymphocyte apoptosis in mice during sepsis, … basis for further exploration of
the treatment of sepsis. Here, we … mechanisms of sepsis as well as therapeutic targets in the …