… and current strategies in sepsis therapy. In this review, we include the two novel therapies
that have … Sepsis-induced thymocyte apoptosis is a relatively newly recognised process in the …

… role of apoptosis in the pathogenesis of sepsis has been explored. Numerous animal studies
have shown that sepsis … Here, we investigate the effect of PI therapy on survival, apoptosis, …

… Antisense therapy against Bcl-2, an anti-apoptotic protein implicated in some forms of
cancer, has shown promise in hematologic malignancies ( 8 ). A clinical trial of drugs that inhibit …

… Sepsis is a major health problem worldwide. As the number of sepsis cases increases,
so does the number of sepsis … consequences of sepsis and how to optimize health post-sepsis. …

… drugs, and antagonistic compounds have shown efficient protection from septic … therapies
have a strong potential for prevention and intervention in infectious diseases, notably sepsis…

… factors and downstream mechanisms within the CNS that associate with septic shock. It
also informs the preventive and therapeutic strategies for sepsis-induced cerebral dysfunction. …

… infection to eventual sepsis and a potential combined therapeutic strategy for targeting …
apoptosis in sepsis (55). Bcl-2 is an anti-apoptosis protein and is found to be reduced in sepsis (…

… analysis and discussion on their therapeutic mechanisms. It is … an exploration of the
etiology and pathogenesis of sepsis, … apoptosis due to endoplasmic reticulum stress in septic …

… These studies also show that sepsis-induced apoptosis of immune cells can … apoptosis is
an important factor in sepsis pathophysiology and provides an important target for therapeutic …

… In this regard, several inhibitory strategies have been applied in animal models,
described below, which may point to novel, therapeutic approaches to shock and sepsis-induced …