[HTML][HTML] Exploring the biomarkers and potential therapeutic drugs for sepsis via integrated bioinformatic analysis

P Liang, Y Wu, S Qu, M Younis, W Wang, Z Wu… - BMC Infectious …, 2024 - Springer
… In sepsis, severe lymphopenia and apoptosis of lymphocytes may be a significant cause
of death [15]. Therefore, the differences in molecular expression patterns linked to …

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

R Li, C Guo, Y Li, Z Qin, W Huang - Briefings in bioinformatics, 2021 - academic.oup.com
… Our bioinformatics analysis clearly showed that the four identified core targets might beneficially
suppress sepsis-associated epithelial cell necrosis or apoptosis in the lung, peritoneum …

Pathological aspects of apoptosis in severe sepsis and shock?

A Ayala, JL Lomas, PS Grutkoski, CS Chung - The International Journal of …, 2003 - Elsevier
… /dysfunction associated with developing sepsis. This is despite the … therapies in these
patients. The inability of these present-day therapies to mitigate the devastating effects of sepsis

[HTML][HTML] Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
therapy have limited prognostic impact in patients with sepsis. … is now recognized as one of
the major causes of septic death. … sepsis-induced apoptosis and improves survival in a CLP …

[HTML][HTML] Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives

D Hu, H Sheeja Prabhakaran, YY Zhang, G Luo, W He… - Critical Care, 2024 - Springer
… to explore the complex mechanisms underlying mitochondrial dysfunction in sepsis and its
… and prevented the reduction of complex activities and apoptosis in hepatocytes [68]. Similar …

The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology

MN Alder, CJ Lindsell, HR Wong - … review of anti-infective therapy, 2014 - Taylor & Francis
… a sepsis outcome risk stratification tool for children with septic shock … Apoptosis of immune
cells is a key step in sepsis-associated immune suppression and while triggers for apoptosis

Therapeutic potential of HMGB1-targeting agents in sepsis

H Wang, S Zhu, R Zhou, W Li… - Expert reviews in molecular …, 2008 - cambridge.org
… enzymes and subsequently undergo apoptotic cell death. Upon … remove the cell debris of
apoptotic neutrophils in order to … It is thus important to further explore the therapeutic potential …

[HTML][HTML] Network pharmacology to explore the anti-inflammatory mechanism of Xuebijing in the treatment of sepsis

W Zhou, X Lai, X Wang, X Yao, W Wang, S Li - Phytomedicine, 2021 - Elsevier
… , immune, cell apoptosis and coagulation of XBJ for treating sepsis were identified. Cell line
… of XBJ may have broad therapeutic effect for sepsis compared to FDA approved drugs or …

Antioxidant therapy for severe sepsis: promise and perspective

MR Pinsky - Critical care medicine, 2003 - journals.lww.com
… event ( 2 ), with increased necrosis and apoptosis of circulating immune effector cells ( 3, 4 ),
… immunomodulating therapy clinical trials in the management of patients with severe sepsis

Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity

R Taneja, J Parodo, SH Jia, A Kapus… - Critical care …, 2004 - journals.lww.com
… antimicrobial therapy, management is entirely supportive. … apoptosis in a cohort of critically
ill ICU patients with sepsis and to … , the delayed neutrophil apoptosis of clinical sepsis differs in …