… that current protocols for therapeutic hypothermia are near-… is earlier diagnosis and initiation
of hypothermia after birth. Further … -ischemic encephalopathy, including add-on therapies for …

… Therapeutic hypothermia is now well established as … –ischemic encephalopathy but is
only partially effective. There is compelling preclinical and clinical evidence that hypothermia is …

… ischemic encephalopathy is a leading cause of neonatal death and disability. Therapeutic
hypothermia … disability associated with hypoxic-ischemic encephalopathy; however, many …

… Use of therapeutic hypothermia for moderate or severe HIE has increased over time and is
… receive treatment with therapeutic hypothermia. Use of therapeutic hypothermia for mild HIE …

… supporting therapeutic hypothermia in newborns with hypoxic ischaemic encephalopathy and
… by prolonged moderate hypothermia, and provides guidance for the clinical application of …

… Therapeutic hypothermia is the recommended treatment for neonates with moderate or …
ischemic encephalopathy (HIE). There is an increasing trend to use therapeutic hypothermia …

… In summary, moderate therapeutic hypothermia used within strict protocols at centres with
experience in therapeutic hypothermia improves the outcome in term and near-term infants …

… . Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced
brain injury on MR biomarkers in mild hypoxic-ischaemic encephalopathy: a non-randomised …

… A combination of the following search terms was hereby used: ‘therapeutic hypothermia,
neonate, hypoxic ischemic encephalopathy and pharmacokinetics’. In PubMed the …

… , therapeutic interventions in HIE remain to be limited. Recently it has been revealed that mild
therapeutic hypothermia … , animal studies of cooling for hypoxic and ischemic models, and …