… We included studies of drugs used for the management of pain or sedation, or both, during
therapeutic hypothermia. This included any opioids (eg morphine, fentanyl), alpha‐2 agonists …

… Nevertheless, achieving optimal sedation and pain control in this cohort is challenging
due … medication used for sedation analgesia during therapeutic hypothermia in neonates. …

… Newborn infants undergoing therapeutic hypothermia (TH) are exposed to multiple painful …
of pain and sedation in newborn infants undergoing TH for hypoxic-ischemic encephalopathy. …

… While the right of universal pain relief is undisputed, it is unclear if morphine … cortical pain
responses.7 Future studies should explore non-pharmacological analgesia during hypothermic …

… Indeed, in vulnerable preterm infants, neonatal pain has been … Moreover, in full-term infants,
neonatal pain may alter pain … Pre-emptive opioid sedation during therapeutic hypothermia …

… To compare two protocols for sedation and analgesia during therapeutic hypothermia: … in
intubated ICU patients prevented us from screening for pain. Fourth, sedatives and analgesics …

… In this context, exposure to pain during neonatal … painful procedures that are essential to
life-saving care. Recent reports suggest that some medications regularly used for sedation in …

… for sedation and analgesia for neonates undergoing TH for HIE. Efficacy was defined as a
reduction in pain … Clinically significant reduction in N-PASS was defined as a reduction in pain …

… therapeutic hypothermia are more likely to receive sedative agents in proximity to the 72-h
examination and that sedation … and best motor response to painful stimulation at that time point…

… We also did not have any data on pain or sedation scores of the babies, and hence are
not able to judge if the opioid sedation was appropriate for individual babies. There was no …