Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
JA McCubrey, LS Steelman, FE Bertrand, NM Davis… - Leukemia, 2014 - nature.com
… pathways can improve leukemia therapy and may overcome therapeutic resistance. In
summary, … and therapeutic resistance. GSK-3 and Wnt are clearly intriguing therapeutic targets. …
summary, … and therapeutic resistance. GSK-3 and Wnt are clearly intriguing therapeutic targets. …
Wnt/β-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease
I Hwang, E Seo, H Ha - Archives of pharmacal research, 2009 - Springer
… Accumulated β-catenin then translocates to the nucleus and regulates the expression of …
In the absence of β-catenin, TCF and Groucho form a constitutive repressor complex. βcatenin …
In the absence of β-catenin, TCF and Groucho form a constitutive repressor complex. βcatenin …
WNT and β-catenin signalling: diseases and therapies
… therapeutic inhibitors of β-catenin signalling include agents that have no obvious link to the
β-catenin … The potential targets for therapeutic intervention in the pathway are described in …
β-catenin … The potential targets for therapeutic intervention in the pathway are described in …
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - … and targeted therapy, 2022 - nature.com
… Although many articles have reviewed Wnt/β-catenin from … /β-catenin signalling pathway
in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin …
in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin …
[HTML][HTML] The regulation of β-catenin activity and function in cancer: therapeutic opportunities
S Shang, F Hua, ZW Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Together, these observations suggest that therapeutic interventions targeting CDK8 may
confer a clinical benefit in β-catenin-driven malignancies. Translational-controlled tumor protein …
confer a clinical benefit in β-catenin-driven malignancies. Translational-controlled tumor protein …
Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours
X Jiang, Y Cao, F Li, Y Su, Y Li, Y Peng… - Nature …, 2014 - nature.com
… Our data demonstrate that β-catenin signalling is an effective therapeutic target for MEN1-…
the activated β-catenin signalling pathway can be targeted for therapeutic interventions of …
the activated β-catenin signalling pathway can be targeted for therapeutic interventions of …
β-catenin-mediated signaling: a molecular target for early chemopreventive intervention
ML Clapper, J Coudry, WCL Chang - Mutation Research/Fundamental and …, 2004 - Elsevier
… of β-catenin by E-cadherin. The common role of β-catenin in both Wnt signaling and cell
adhesion provides a unique opportunity to develop chemopreventive therapies that both …
adhesion provides a unique opportunity to develop chemopreventive therapies that both …
[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy
D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
… In summary, this systemic review examined the intervention of natural small molecules on
Wnt/β-catenin pathway with respect to initiation and progression of cancers, renal diseases, …
Wnt/β-catenin pathway with respect to initiation and progression of cancers, renal diseases, …
Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer
Y Ji, J Lv, D Sun, Y Huang - … journal of molecular …, 2022 - spandidos-publications.com
… Therefore, the Wnt/β‑catenin signaling pathway has potential value as a therapeutic target
… and the promoting or suppressing function of therapeutic targets on CRC were explored. In …
… and the promoting or suppressing function of therapeutic targets on CRC were explored. In …
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
… The Wnt pathway cross talks with the Notch and Sonic Hedgehog pathways, which has
implications for therapeutic interventions in cancers. There are significant challenges in targeting …
implications for therapeutic interventions in cancers. There are significant challenges in targeting …
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