… Here, we report cryo electron microscopy (cryo-EM) structural analyses of full-length wild-…
Mutational analysis of KIT reveals in D5 region an “Achilles heel” for therapeutic intervention. A …

… of protein targets for therapeutic intervention, until relatively … suggest for this kind of analysis
is 4.2 Å for cryo-EM maps). The vast … , data collection and data analysis over previous years. …

… imaging analysis and the … cryo-EM has impacted drug discovery in diverse therapeutic
areas. Targets that have been brought into the realm of structure-based drug design by cryo-EM …

… application of structural analysis based on cryo-EM more and … This new software can work
without user intervention to a … herpesvirus for targeted treatment. Wang et al.65 determined the …

… cryo–electron microscopy (cryo-EM) structural analysis … than those used in our cryo-EM study
were reported to be … cannot completely exclude their involvement in tetrameric intasomes (…

… The therapeutic interventions that reduce circulating cholesterol levels (5), such as statins …
detergent digitonin for cryo-EM analysis (fig. S1). We initially obtained a cryo-EM density map …

… ] suggested that cryo-EM single-particle analysis could reach atomic resolution for
macromolecular complexes as small as 100 kDa. For many years, this prospect seemed overly …

… Our structural and functional analyses indicate that binding of … for the eventual therapeutic
intervention of diseases caused … Our functional analyses indicate that site 1 and site 2 are both …

… 3D cryo-electron microscopy (cryo-EM) is an expanding … Therefore, cryo-EM can be used
to investigate complete and … behind the cryo-EM methodology of single particle analysis and …

… Here, we present cryo-electron microscopy structures at 2.8 to … that selectively target Pol III
for therapeutic interventions. … subjected our cryo-EM reconstructions to 3D variability analysis (…