… by mutations of the gene encoding PERK (EIF2AK3), which … of the UPR and its therapeutic
modulation have been most well … intrinsic and extrinsic apoptotic pathways 25 . TUDCA may …

… pathways regulating tumor-associated inflammation and antitumor immunity. We primarily
focus on the relevance of therapeutic modulation … a pathway that requires PERK modulation of …

… ER stress is the modulation of individual UPR pathways such as PERK/eukaryotic initiation
… the signalling pathways of the UPR could be modulated to establish therapeutic strategies to …

… or modulating protein quality control; and (ɛ) modulating the adaptive response of the secretory
pathway… p58IPK-mediated attenuation of the pro-apoptotic PERK-CHOP pathway allows …

… modulated PERK signaling in cell culture models of tau aggregation and found that PERK
pathway … -molecule augmentation of PERK signaling as an attractive therapeutic strategy to …

… UPR signaling can be mediated by the PERK protein, and this pathway may mitigate the
effects of DHA in glioma cell lines. Therefore, the treatment with this drug also activated, in …

… to explore the therapeutic potential of UPR modulation have … genetic inhibition of PERK
signaling pathway in mutant SOD1-… Since ISRIB modulates PERK-dependent translational …

… During ER stress, PERK dissociates from GRP78 and is responsible for the global … (37)
Because eIF2α, ATF4, and CHOP are downstream regulators of the PERK pathway and are …

… whether STAT3 was an upstream modulator of the PERK signal pathway. Our findings firstly
… be an upstream modulator of the PERK branch. From a therapeutic viewpoint, increasing …

… therapeutic target of CKD. Therefore, the activation of tolvaptan/PERK/Nrf2/HO-1 signaling
pathway is a potential therapeutic … and subsequently modulate PERK phosphorylation without …