… In the present work, we will focus on the proposed nanosystems for targeting hepatic
macrophages in order to improve pathological processes in the liver. The role of macrophages in …

… This review will summarize the current knowledge of the hepatic macrophages, their origin,
… overview of the therapeutic targeting strategies against hepatic macrophages developed for …

… in the progression or regression of liver diseases has resulted in manifold concepts for
macrophage-directed therapies. The whole cascade of initial injury recognition by Kupffer cells, …

… The preferential hepatic … up by hepatic immune cells, that is, macrophages >dendritic cells
>T cells (up to 70% after one injection), but not by hepatocytes. Such a degree of macrophage …

… liver macrophages to be an anti-inflammatory M2 phenotype, effectively reduce hepatic
lobular … This study provided an effective delivery system and therapeutic strategy for NASH. …

… However, the various populations of hepatic macrophages … development of macrophage-based
therapeutic interventions. … of hepatic macrophages, their functions in maintaining hepatic …

… that shows the therapeutic potential of targeting macrophages in metabolic diseases as well
… of hepatic macrophage subsets has been shown to successfully suppress hepatic steatosis …

… Macrophages next to the hepatic artery and portal vein are more phagocytic than … Unintended
accumulation of therapeutic nanoparticles into liver macrophages can drive toxicity and …

… Hepatic macrophages arise from circulating bone-marrow-derived monocytes, which are …
from proliferating resident macrophages (Kupffer cells). Resident macrophages have shown to …

… This technology may hold exceptional potential for novel therapeutic approaches to liver
diseases. The specific and unspecific targeting of macrophages, hepatic stellate cells (HSC), …