… appetite via the leptin receptor. … leptin and leptin receptor expression, particularly in
cancers and tumor microenvironments, and characterized the role of this signaling axis in cancer …

… receptor signaling may represent a potential therapeutic target that can block the stromal-…
as a fundamental environmental regulator of CSCs in the cancer stem niche. Indeed, either …

… receptors are overexpressed in multiple types of cancer, … concerning the role of leptin in
obesity-related cancers. Finally, we … to design novel therapies that may impair leptin signaling in …

… Therapeutic resistance in cancer occurs when leptin … response and resistance to neoplastic
therapies; For this reason, … This physicochemical niche includes endothelial cells, fibroblasts…

… niche. … cancer treatments; hence, understanding how CSCs are initiated and maintained
by the tumor microenvironment will have an impact on development of more effective therapies. …

… adapted to specific obesity forms and cancer therapies. This review aims to summarize the
current knowledge on the potential associations of leptin genetics with the main pathogenic …

… with non-cancerous breast epithelial cells [31]. Leptin and leptin receptors regulate multiple
… CAAs reshape the metabolic niche of the ECM by altering the metabolism of BC cells to …

… Using the intra-iliac injection-based experimental metastasis model (Table 1), we (XH-FZ)
showed that the cancer–osteogenic niche interaction was mediated by heterotypic adherens …

… the maintenance and proliferation of the stem cell niche, cell fate decisions and can drive …
studies suggested that IMR-1 could be a new promising anti-Notch therapy for cancer [108]. …

… CSCs hide in the tumor niche causing relapse and metastasis. The tumor … could be a novel
therapeutic target for obese PC patients. We further determined the effects of leptin on HDAC …