Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia

ED Huey, N Armstrong, P Momeni… - … opinion on therapeutic …, 2008 - Taylor & Francis
… of drug therapies for frontotemporal dementia spectrum … of frontotemporal dementia spectrum
disorders; second, a discussion of the challenges in the development of drug therapies third…

[HTML][HTML] New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia

S Amin, G Carling, L Gan - Current Opinion in Neurobiology, 2022 - Elsevier
Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the
frontal … We also review the opportunities and challenges toward developing therapies and …

Advances in treatment of frontotemporal dementia

N Magrath Guimet… - The Journal of …, 2022 - Am Neuropsych Assoc
… a behavioral therapy called “routinizing therapy”—in which stimulus-bound and stereotypic
behaviors are replaced with appropriate behaviors—improved. This therapy was reported to …

Therapeutic trial design for frontotemporal dementia and related disorders

P Desmarais, JD Rohrer, QD Nguyen… - Journal of Neurology …, 2019 - jnnp.bmj.com
… The frontotemporal dementia (FTD) spectrum is a heterogeneous group of neurodegenerative
syndromes with overlapping clinical, molecular and pathological features, all of which …

Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations

BF Boeve, AL Boxer, F Kumfor, Y Pijnenburg… - The Lancet …, 2022 - thelancet.com
frontotemporal lobar degeneration. This Review will use the term frontotemporal dementia
when focusing on the clinical syndromes of behavioural variant of frontotemporal dementia

New directions for frontotemporal dementia drug discovery

JQ Trojanowski, K Duff, H Fillit… - … & Dementia, 2008 - Wiley Online Library
… by TDP-43 proteinopathy will benefit from neuroprotective therapies in the absence of clear
therapeutic strategies that could benefit both tauopathies and TDP-43 proteinopathies. …

Approaches to develop therapeutics to treat frontotemporal dementia

LP Elia, T Reisine, A Alijagic, S Finkbeiner - Neuropharmacology, 2020 - Elsevier
Frontotemporal dementia is the second prevalent dementia after Alzheimer's disease. …
Efforts to raise PGRN levels are a therapeutic strategy for frontotemporal dementia. …

Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options

GA Jicha, PT Nelson - Neurodegenerative disease management, 2011 - Taylor & Francis
therapies for the management of frontotemporal dementia (FTD)… Progress in obtaining approval
and therapeutic indications for … and publications investigating therapeutic options in FTD, …

New routes in frontotemporal dementia drug discovery

L De Conti, B Borroni, M Baralle - Expert Opinion on Drug …, 2017 - Taylor & Francis
… Introduction: Research into the pathogenic mechanisms behind frontotemporal dementia
(FTD) has yielded several new targets for therapeutic intervention; such targets include specific …

Promising therapies for the treatment of frontotemporal dementia clinical phenotypes: from symptomatic to disease-modifying drugs

G Logroscino, BP Imbimbo, M Lozupone… - Expert opinion on …, 2019 - Taylor & Francis
Frontotemporal dementia (FTD) is a heterogeneous clinical entity that includes several
disorders characterized by different cellular mechanisms, involving different brain regions, with …