[HTML][HTML] Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

D Ajmeera, R Ajumeera - Genes & Diseases, 2024 - Elsevier
… non-cancerous drugs with anticancer activity… drug repurposing and the combination of
micronutrients that can target both cancers and cancer stem cells may result in a better therapeutic

Overcoming therapy resistance in colon cancer by drug repurposing

T El Zarif, M Yibirin, D De Oliveira-Gomes… - Cancers, 2022 - mdpi.com
… current data supporting drug repurposing as a … drug repurposing as a feasible option for
patients with CRC with a focus on the evidence and mechanism of action promising repurposed

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - … and targeted therapy, 2020 - nature.com
… non-oncology drugs for clinical cancer management and classify these candidates into their
… - or drug combination therapy. We also summarize approaches used for drug repurposing

Drug repurposing to overcome resistance to various therapies for colorectal cancer

W Fong, KKW To - Cellular and molecular life sciences, 2019 - Springer
… While novel drug development is unfavorable in terms of time frame and costs, drug
repurposing is one of the promising strategies to combat resistance. This approach refers to the …

[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
… discovery and the development of bacterial resistance. We summarize drug-drug interactions
and uncover the art of repurposing non-antibiotic drugs as potential antibiotic adjuvants, …

Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
… vitro antimicrobial activity to support existing anti-infective therapeutics is provided, including
several critical remarks on this strategy of repurposing non-antibiotics to antibacterial drugs. …

Overcoming drug resistance in advanced prostate cancer by drug repurposing

HF Bahmad, T Demus, MM Moubarak, D Daher… - Medical …, 2022 - mdpi.com
… , affecting stromal, endothelial, and immune cells, as well as promoting epithelial-to-mesenchymal
transition, which is believed to be a contributor to therapy resistance in PCa [20,21]. …

Drug repurposing—an emerging strategy in cancer therapeutics

KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
… may make them suitable to be repurposed as cancer therapeutics (Fig. 1). This review article
also includes the clinical trial status of repurposed drugs, which are currently being focused …

Repurposing old drugs to fight multidrug resistant cancers

J Dinić, T Efferth, AT García-Sosa, J Grahovac… - Drug Resistance …, 2020 - Elsevier
resistance represents a major challenge for cancer treatment. In the search for new
chemotherapeutics to treat malignant diseases, drug repurposing … for cancer therapeutics. These …

[HTML][HTML] Improving therapy of severe infections through drug repurposing of synergistic combinations

YS Cheng, PR Williamson, W Zheng - Current opinion in pharmacology, 2019 - Elsevier
… in 2014, our group performed a drug repurposing screen which identified a set of 53
Ebola-entry inhibitors [45]. However, the human plasma drug concentrations of most of these …