The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
DE Biancur, AC Kimmelman - … Biophysica Acta (BBA)-Reviews on Cancer, 2018 - Elsevier
… Together, these unique pathways for nutrient utilization and acquisition result in metabolic
… of the intense therapeutic resistance. In this review, we discuss metabolic pathways in PDA …
… of the intense therapeutic resistance. In this review, we discuss metabolic pathways in PDA …
[HTML][HTML] Drug resistance in pancreatic cancer: Impact of altered energy metabolism
C Grasso, G Jansen, E Giovannetti - Critical reviews in oncology …, 2017 - Elsevier
… These studies can potentially bridge a shift of focus to novel targets for therapeutic
intervention in PDAC, including metabolic reprogramming. Understanding how best to integrate …
intervention in PDAC, including metabolic reprogramming. Understanding how best to integrate …
Autophagy contributes to metabolic reprogramming and therapeutic resistance in pancreatic tumors
G Reyes-Castellanos, N Abdel Hadi, A Carrier - Cells, 2022 - mdpi.com
… of pancreatic cancer is its highly therapeutic resistance due to some … Among these features,
metabolic aberrations, including … therapeutic resistance via autophagy in pancreatic cancer. …
metabolic aberrations, including … therapeutic resistance via autophagy in pancreatic cancer. …
[HTML][HTML] The landscape of pancreatic cancer therapeutic resistance mechanisms
… current therapeutic resistance mechanisms both extrinsically including the tumor
microenvironment … This study provides rationale for targeting cellular metabolism in converting …
microenvironment … This study provides rationale for targeting cellular metabolism in converting …
Metabolism of pancreatic cancer: paving the way to better anticancer strategies
C Qin, G Yang, J Yang, B Ren, H Wang, G Chen… - Molecular cancer, 2020 - Springer
… metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of
pancreatic cancer … after employing therapies that regulate metabolism. Thus, investigations of …
pancreatic cancer … after employing therapies that regulate metabolism. Thus, investigations of …
The complex landscape of pancreatic cancer metabolism
CM Sousa, AC Kimmelman - Carcinogenesis, 2014 - academic.oup.com
… In addition to a large amount of intertumoral heterogeneity, there is also significant
intratumoral heterogeneity that may have implications on the intense therapeutic resistance (45). …
intratumoral heterogeneity that may have implications on the intense therapeutic resistance (45). …
The biological underpinnings of therapeutic resistance in pancreatic cancer
GL Beatty, G Werba, CA Lyssiotis… - Genes & …, 2021 - genesdev.cshlp.org
… question concerning pancreatic tumor metabolism and, specifically, how metabolism and
growth … In summary, pancreatic cancer cells may use metabolic programs as a means to evade …
growth … In summary, pancreatic cancer cells may use metabolic programs as a means to evade …
Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
… therapeutic resistance prevails. This resistance underscores the resilience of pancreatic cancer
and … deprives cancer cells of essential metabolic needs and induces cell death. Similarly, …
and … deprives cancer cells of essential metabolic needs and induces cell death. Similarly, …
[HTML][HTML] Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities
A Jain, V Bhardwaj - World journal of gastroenterology, 2021 - ncbi.nlm.nih.gov
… therapy resistance and how a better understanding of these mechanisms has shaped clinical
trials for pancreatic cancer … Below we discuss the central carbon metabolic pathways — …
trials for pancreatic cancer … Below we discuss the central carbon metabolic pathways — …
[HTML][HTML] Overcoming therapy resistance in pancreatic cancer: New insights and future directions
M Espona-Fiedler, C Patthey, S Lindblad, I Sarró… - Biochemical …, 2024 - Elsevier
… The role of fatty acids in pancreatic cancer is complex and still unclear. Nonetheless, the
number of preclinical and clinical studies based on metabolism-targeted therapies such as …
number of preclinical and clinical studies based on metabolism-targeted therapies such as …
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- drug resistance in pancreatic cancer
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