… Together, these unique pathways for nutrient utilization and acquisition result in metabolic
… of the intense therapeutic resistance. In this review, we discuss metabolic pathways in PDA …

… These studies can potentially bridge a shift of focus to novel targets for therapeutic
intervention in PDAC, including metabolic reprogramming. Understanding how best to integrate …

… of pancreatic cancer is its highly therapeutic resistance due to some … Among these features,
metabolic aberrations, including … therapeutic resistance via autophagy in pancreatic cancer. …

… current therapeutic resistance mechanisms both extrinsically including the tumor
microenvironment … This study provides rationale for targeting cellular metabolism in converting …

… metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of
pancreatic cancer … after employing therapies that regulate metabolism. Thus, investigations of …

… In addition to a large amount of intertumoral heterogeneity, there is also significant
intratumoral heterogeneity that may have implications on the intense therapeutic resistance (45). …

… question concerning pancreatic tumor metabolism and, specifically, how metabolism and
growth … In summary, pancreatic cancer cells may use metabolic programs as a means to evade …

… therapeutic resistance prevails. This resistance underscores the resilience of pancreatic cancer
and … deprives cancer cells of essential metabolic needs and induces cell death. Similarly, …

… therapy resistance and how a better understanding of these mechanisms has shaped clinical
trials for pancreatic cancer … Below we discuss the central carbon metabolic pathways — …

… The role of fatty acids in pancreatic cancer is complex and still unclear. Nonetheless, the
number of preclinical and clinical studies based on metabolism-targeted therapies such as …