Asthma is a complex clinical syndrome with multiple genetic and enviromental factors
contributing to its phenotypic expression. This aetiological heterogeneity adds to the complexity …

… between asthma and COPD, or do the two represent a continuum? Do asthmatics and patients
… hyperinflation and its response to bronchodilators more typical of COPD or asthma? Also, …

… asthma therapies. However, this study demonstrates the less-than-uniform response in
FEV 1 and variability in patient response to asthma therapy. The findings imply that individual …

… asthma phenotypes, we aim to detect whether those clinical asthma phenotypes may affect
the response … results into a simple clinical guide that can help to tailor the asthma medicines. …

… [58] reported that the eosinophil percentage in the blood was a predictor of a therapeutic
response in adults with asthma, yet the baseline values of clinical parameters used as outcome …

… In this section, we focus our discussion on the segmentation of therapy in severe asthma [as …
therefore predicts therapy response. As summarized in Figure 1, our therapeutic strategy is …

… A good example is the observation that blood eosinophilia predicts therapeutic responses
to all currently available or future-targeted interventions in severe asthma (ie, anti-IL-5, IL-4/IL-…

… with severe asthma. Anti-IgE therapy is beneficial in selected patients with severe asthma. …
and might benefit patients with subtypes of severe asthma. Several broad-spectrum anti-…

… In conclusion, the distribution and overlap of patient responses (as assessed by asthma …
6 weeks of therapy there is a generally similar distribution of response seen with montelukast …

… therapeutic response patterns to salbutamol. Almost 70% of patients were sensitive to salbutamol
(good response … In the remainder 30% of patients (poor response pattern), salbutamol …