过去一年中添加的文章，按日期排序

Suppression of NLRP3 inflammasome orchestrates the protective efficacy of tiron against isoprenaline-induced myocardial injury

D Abdelrahaman, O Habotta, ES Taher… - Frontiers in … - frontiersin.org
2 天前 - … The major contribution of myocardial damage to global mortalities arouses debate
regarding the exploration of new therapeutic strategies for its treatment. Therefore, our study …
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Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway

A Wang, G Zhong, M Ying, Z Fang, Y Chen, H Wang… - …, 2024 - Elsevier
4 天前 - … Notably, the use of MCC950 in Parkin +/- mice did not ameliorate NLRP3 inflammasome
… NLRP3 inflammasome activation is expected to be a potential therapeutic strategy for …
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[HTML][HTML] DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering

O Sandys, PCF Stokkers, AA Te Velde - Digestive Diseases and Sciences, 2024 - Springer
6 天前 - … strategy that addresses its variability. One approach often overlooked by the
pharmaceutically driven therapeutic … , for example, the NLRP3 inflammasome—a major amplifier …
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UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier

L Ran, M Chen, J Ye, S Zhang, Z Luo, T Bai… - Advanced …, 2024 - Wiley Online Library
9 天前 - … NLRP3 inflammasome has been recognized as a promising therapeutic strategy for
the … Here, it is shown that UK5099 is a potent inhibitor of the NLRP3 inflammasome in both …
相关文章 所有 3 个版本

Unraveling the Triad: Hypoxia, Oxidative Stress and Inflammation in Neurodegenerative Disorders

TC Dakal, K Choudhary, I Tiwari, V Yadav, PK Maurya… - Neuroscience, 2024 - Elsevier
15 天前 - … therapeutic approach for age-related brain diseases. Recent findings indicate that
the involvement of HIF-1α and the NLRP3 inflammasome … Additional therapy strategies aimed …
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[HTML][HTML] Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes

J Guan, H Abudouaini, K Lin, K Yang - Diabetology & Metabolic Syndrome, 2024 - Springer
15 天前 - … therapeutic potential of IL-1 inhibitors and colchicine, highlighting their mechanisms
in inhibiting the NLRP3 inflammasome … implementing targeted therapeutic strategies aimed …
相关文章 所有 6 个版本

Development of CRID3-Based Anti-inflammatory Agents to Ameliorate Chronic Hypoxia-Induced Memory Impairment in Zebrafish Models

K Soren, RK Bollikanda, T Das, S Patel… - ACS Chemical …, 2024 - ACS Publications
20 天前 - … In this study, we focused on the NLRP3 inflammasome … molecule inhibitors for the
NLRP3 inflammasome, to investigate … in developing therapeutic strategies for neurological …
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Discovery and Development of NLRP3 Inhibitors Targeting the LRR Domain to Disrupt NLRP3-NEK7 Interaction for the Treatment of Rheumatoid Arthritis

B Li, P Li, L Wei, J Zou, Y Wang, Q You… - Journal of Medicinal …, 2024 - ACS Publications
22 天前 - … Targeting NLRP3 inflammasome, specifically its interaction with NEK7 via the
LRR domain of NLRP3, is a promising therapeutic strategy. Our research aimed to disrupt this …
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Platelets in Kawasaki disease: mediators of vascular inflammation

M Noval Rivas, B Kocatürk, BS Franklin… - Nature Reviews …, 2024 - nature.com
23 天前 - … Platelets boost NLRP3 inflammasome activation and IL-1β production by human …
disease vasculitis and therapeutic strategies targeting platelets or platelet-derived molecules. …
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[HTML][HTML] Network pharmacology and experimental validation to explore the mechanism of Changji'an formula against irritable bowel syndrome with predominant …

W Ke, J Wu, H Li, S Huang, H Li, Y Wang, Y Wu, J Yuan… - Heliyon, 2024 - cell.com
23 天前 - … κB/NLRP3 inflammasome pathway … /NLRP3 signaling pathway. This study not only
reveals the mechanism of CJAF against IBS-D, but also provides a novel therapeutic strategy …
相关文章 所有 2 个版本