Novel molecular targets for atrial fibrillation therapy
… fibrillation, and several new compounds are under development. This Review focuses on …
of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on …
of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on …
Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic target
JS Healey, SJ Connolly - The American journal of cardiology, 2003 - Elsevier
… , left atrial enlargement, and slowing of atrial conduction velocity. … of atrial fibrillation, and
they increase the risk of thromboembolic complications. Conventional therapy of atrial fibrillation …
they increase the risk of thromboembolic complications. Conventional therapy of atrial fibrillation …
A new therapeutic framework for atrial fibrillation drug development
YS Ang, S Rajamani, SM Haldar, J Hueser - Circulation research, 2020 - Am Heart Assoc
… myopathy provides many new opportunities for detailed understanding of underlying
mechanisms and can guide identification of therapeutic targets that extend well beyond the …
mechanisms and can guide identification of therapeutic targets that extend well beyond the …
Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target
DR Van Wagoner - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial fibrillation (AF) is one of the most prevalent and vexing cardiovascular conditions.
Available treatments for AF based on ion channel blockade are only poorly effective. The …
Available treatments for AF based on ion channel blockade are only poorly effective. The …
EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation
S Song, R Zhang, B Mo, L Chen, L Liu, Y Yu… - Journal of molecular and …, 2019 - Elsevier
… and atrial fibrosis and AF. Next, we further validated the relationship between EZH2 and
atrial fibrillation using two atrial fibrosis animal models. Mice developed significant atrial fibrosis …
atrial fibrillation using two atrial fibrosis animal models. Mice developed significant atrial fibrosis …
Role of tumor necrosis factor alpha in the pathogenesis of atrial fibrillation: a novel potential therapeutic target?
M Ren, X Li, L Hao, J Zhong - Annals of medicine, 2015 - Taylor & Francis
… the related mechanisms, and exploits its potential usefulness as a novel therapeutic target.
… be a good prognostic biomarker and novel potential therapeutic target for atrial fibrillation. …
… be a good prognostic biomarker and novel potential therapeutic target for atrial fibrillation. …
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke
R Zou, D Zhang, L Lv, W Shi, Z Song, B Yi, B Lai… - Journal of translational …, 2019 - Springer
… Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, … between
atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF…
atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF…
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
… Our purpose is to highlight a shared mechanism linking HF and AF that is also a
therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …
therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …
… into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system
R Arora - Circulation: Arrhythmia and Electrophysiology, 2012 - Am Heart Assoc
… approaches targeting the autonomic innervation of the atria, we also describe recent biological
(gene therapy) attempts to selectively disrupt parasympathetic signaling in the atria using …
(gene therapy) attempts to selectively disrupt parasympathetic signaling in the atria using …
Inflammation, inflammasome activation, and atrial fibrillation: evidence for causation and new therapeutic targets
DR Van Wagoner, MK Chung - Circulation, 2018 - Am Heart Assoc
… , contributing to atrial ectopy that can initiate episodes of atrial fibrillation. ASC indicates …
atrial tissues, we reported downregulation of heat shock factor 1 and heat shock factor 2 targets …
atrial tissues, we reported downregulation of heat shock factor 1 and heat shock factor 2 targets …
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