… Based on the above discussion, several key regulators of Ca2+ homeostasis emerge as
potential therapeutic targets in failing cardiomyocytes, namely i) SERCA2a, ii) NCX, iii) RyR and …

… At the same time as Ca2+ overload, cardiomyocytes abruptly develop cell edema after
reperfusion as a result of osmotic loading during ischemia. ATP production restituted by re-supply …

… (sarcolemmal) ultrastructure of cardiomyocytes and the rich … the vast majority of cardiomyocytes
purposed to mechanical … cardiomyocytes) couples to contraction by a Ca 2+ -induced …

… Istaroxime, (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride) enhances
SR Ca 2+ content and Ca 2+ uptake in failing cardiomyocytes and improves heart function …

… a therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …
, including Ca 2+ entry into cardiomyocytes 12 , intracellular Ca 2+ release from the SR 27 , …

… Since reduced SERCA2 activity has been tightly coupled to contractile dysfunction in chronic
heart disease, increasing SERCA activity is an important therapeutic goal. Early clinical trial …

… to deliver Ca 2+ from the cytosol into the lumen of the SR against the concentration gradient
hydrolyzing one ATP molecule for each 2 Ca 2+ in diastolic phase of the cardiomyocyte. …

… Since the L-type Ca2+ channel is the main route for calcium influx into cardiac myocytes and
… induce cardiac hypertrophy in cardiac myocytes via activation of the L-type Ca2+ channel. …

… Ca 2+ -induced Ca 2+ release in cardiomyocytes and RyR2 macromolecular complex. A.
SR Ca 2+ release is initiated by Ca 2+ entry into the cell through the activation of L-type Ca 2+ …

… Therapeutic Target and PubMed Databases. The data analysis showed that six drugs and
corresponding targets are used … The main cardiomyocyte Ca 2+ storing organelles are SR and …