… Therefore, since MDSCs may be therapeutic target cells for sepsis-induced … CTLA-4
antibody treatment attenuates sepsis-induced apoptosis and improves survival in a …

… the first 6 hours and mortality in severe sepsis and septic shock [10]. We have also shown
that early goal-directed therapy targeting global tissue hypoxia to be more effective than …

… following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited
signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 …

… for newer therapeutic targets in sepsis is still on and miRNAs could be the potential targets.
… to prevent apoptosis and organ damage in sepsis [168, 169]. The inhibition of miR-195 in …

… in various animal models of septic shock and hypothesize that … septic shock. Identification
of condition(s) co-activating these processes may provide useful therapeutic targets for sepsis. …

… trials and therapies aimed at targeted treatment based on … used to block TLR-related
pathways may have failed to show … refuting a central role for apoptosis in septic AKI, and argue …

… It compactly covers most of the research being performed in the apoptotic … therapeutic
approaches. However, not only are novel targets discussed, but also tumor specific drug targeting, …

… therapeutic target for sepsis (41). … apoptosis has been demonstrated to lower sepsis mortality
(70). However, delayed neutrophil apoptosis negatively contributed to the severity of sepsis …

… being elucidated, and this may offer new therapeutic targets in the care of septic patients. …
by immune-cell apoptosis and enhanced expression of negative regulators of TLR signalling. …

… response syndrome and sepsis ( 69, 70 ). Targeting apoptosis of Tregs may be a new
therapeutic approach in preventing the continuum of sepsis to severe sepsis. However, it has been …