Potential therapeutic targets for Parkinson's disease

J Stoessl - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: Parkinson's disease is a common disorder that becomes more prevalent with
advanced age. The cardinal features are related to dopamine deficiency, arising from loss of …

[HTML][HTML] Mitochondria: a therapeutic target for Parkinson's disease?

Y Luo, A Hoffer, B Hoffer, X Qi - International journal of molecular sciences, 2015 - mdpi.com
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The
exact causes of neuronal damage are unknown, but mounting evidence indicates that …

[HTML][HTML] Current and emerging therapeutic targets for Parkinson's disease

T Pingale, GL Gupta - Metabolic Brain Disease, 2021 - Springer
… models, the safety issue of these targets needs to be analyzed before entering into the
clinical trial phase. Moreover, the novel therapeutic targets discussed in the current review offer …

Neurotrophic factors as a therapeutic target for Parkinson's disease

JR Evans, RA Barker - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
… before we conclude with a discussion of the potential of NTFs as a therapeutic target in PD.
… it a more attractive therapeutic target in PD, one with the ability perhaps to target both motor (…

α-Synuclein: A therapeutic target for Parkinson's disease?

KA Maguire-Zeiss - Pharmacological research, 2008 - Elsevier
… both familial forms of the disease and animal models places … disease is currently without a
cure and most therapies target … in disease pathogenesis and as a potential therapeutic target

The parkin protein as a therapeutic target in Parkinson's disease

KF Winklhofer - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
Parkinson's disease (PD) is the most common movement disorder and the second most common
neurodegenerative disease after Alzheimer's disease… an attractive target for therapeutic

[HTML][HTML] Zona incerta as a therapeutic target in Parkinson's disease

K Ossowska - Journal of neurology, 2020 - Springer
The zona incerta has recently become an important target for deep-brain stimulation (DBS)
in Parkinson’s disease (PD). The present review summarizes clinical, animal and anatomical …

Iron as a therapeutic target for Parkinson's disease

C Moreau, JA Duce, O Rascol… - Movement …, 2018 - Wiley Online Library
… Ferroptosis as a therapeutic target in Parkinson's disease. Alterations in the iron regulatory
pathway and phospholipid oxidation are implicated in Parkinson's disease pathology. …

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

A Cuadrado, P Moreno-Murciano… - … on therapeutic targets, 2009 - Taylor & Francis
… in the etiopathology of Parkinson's disease (PD) and as a result new therapeutic targets for
… 2 (Nrf2), as a pharmacological target for neuroprotective therapy in PD. Data generated by …

[HTML][HTML] The Epigenome as a therapeutic target for Parkinson's disease

SV Hegarty, AM Sullivan… - Neural regeneration …, 2016 - journals.lww.com
Parkinson's disease (PD) is a common, progressive neurodegenerative disease characterised
by degeneration of nigrostriatal dopaminergic neurons, aggregation of α-synuclein and …