The mammalian target of rapamycin (mTOR) is centrally located, linking proximal oncogenic
cascades to critical downstream pathways that drive tumor growth. mTOR regulates such …

… that RAP and other therapeutics targeting mTOR may be particularly … pathways and kinases
that mediate these cell transforming effects may lead to the development of both therapeutic …

… target of rapamycin (mTOR) pathway plays a central role in controlling protein homeostasis
and negatively regulates autophagy. Inhibition of mTOR by rapamycin … therapeutic target for …

… pathways activated by amino acids, insulin, growth factors, and stress mediators like starvation
and hypoxia. The PI3K/Akt pathway is one of the major pathways … a therapeutic target has …

… In addition to its actions on p70 s6k and 4E-BP1, rapamycin … Both rapamycin and CCI-779,
an ester analog of rapamycin … targeting rapamycin-sensitive signal-transduction pathways. CCI…

… The target of rapamycin (TOR) signaling pathway has … This review focuses on TOR as a
therapeutic target in cancer, a … approval of the mammalian target of rapamycin (mTOR) inhibitor, …

… Inhibition of TOR in vivo, utilising its namesake rapamycin, … use of rapamycin and its
derivatives as a therapeutic agent in … exploited in the therapeutic application of rapamycin to drug …

… The demonstration of rapamycin’s antineoplastic properties, initially in an National Cancer
Institute (NCI) screening program, identified of mTOR as a potential therapeutic target, which …

… target of rapamycin (mTOR) pathway is an attractive avenue for drug development, as agents
targeting … the repression of apoptosis and the resistance to cytotoxic therapy in cancer cells. …

… A well-known mTOR inhibitor is rapamycin (RAPA), previously applied as an … targeting
the mTOR kinase pathway. Mammalian target of rapamycin (mTOR) kinase as a target …