… Given that the position of YB-1 is upstream of the … , YB-1 is a very attractive therapeutic target.
Several approaches to target YB-1 have been employed, including targeting of YB-1 directly…

… Thus, nuclear YB-1 appears to be a potential target for the inhibition of Her-2- and ERα-…
to Her-2-targeting drugs such as trastuzumab. In some cancers, YB-1 may be involved in …

… YB-1 promotes the progression of multiple tumor types and serves as a potential tumor
biomarker and therapeutic target. … of YB-1 in cancers, and further discusses targeted strategies. …

… YB-1 … YB-1 were further stimulated by its identification as a marker of malignant cell
transformation and tumor aggressiveness and as a promising molecular target in the therapy …

… Of note, determining the molecular mechanism underlying the YB-1-mediated NF-κB …
identifying new therapeutic targets for intervention in cancer. We predict that targeting YB-1 should …

… : IMPDH1 maintained YB-1 protein stabilization; YB-1 induced … physically interacted with
YB-1 and translocated YB-1 into the … theoretical rationale for targeting the IMPDH1/YB-1 axis to …

… In conclusion, although YB-1 seems to be an attractive target for tumour therapy, due to its
… of a suitable therapeutic strategy in order to target the oncogenic function of YB-1 in cancer …

… box binding protein-1 (YB-1) could serve as one such target. Recent … Here, we review the
regulation of YB-1 at the transcriptional, … its potential use as a biomarker and therapeutic target. …

… rearrangements, transcription factor YB-1 and CpG methylation on … We also demonstrated
that YB-1 modulates not only … targets for anticancer therapeutics. (Cancer Sci 2003; 94: 9–14) …

… Based on these data YB-1 targeting was indicated as a promising therapeutic … Therapeutic
targeting of glycolysis in cancer patients has been proposed as a potential therapeutic …