… The focus of research to identify NSCLC drug targets has shifted from studying cancer-cell
autonomous functions to include the tumor microenvironment:stromal cells, ECM components …

The tumor microenvironment (TME) is cellular environment in addition to harboring carcinoma
cells, consists of different components (eg, blood vessels, immune cells, fibroblasts, bone …

… therapies.71 Well-designed nanomaterials to specifically target tumor microenvironment or
tumor … Some therapeutic targets, such as integrin α v β 3 and MT1-MMP, are upregulated in …

… angiogenesis in general, and MM BM angiogenesis in particular, we aim to identify additional
therapeutic targets, to further optimize treatment regimens; and to reduce mechanisms …

… Tumour microenvironment (TME) therapeutic targeting has long been seen as a … therapies
in light of targeting TME. We also cover problems related to the TME-targeted therapies, as …

… The tumor microenvironment participates in all stages of tumor progression and has
emerged as a promising therapeutic target for cancer therapy. Rapid progress in the field of …

… the tailored design of nanorobots, along with optimal therapeutic targets and drug models,
demonstrates unprecedented potential toward satisfactory tumor therapeutic effectiveness. …

… from normal counterparts but also can be used as specific therapeutic targets for tumor
treatment. Some small-molecule inhibitors that target CAFs have been developed (Table 3) [[113]…

… enhances the development of CSCs in the tumor microenvironment. Targeting HIFs in
combination with other common therapeutics is pre-requisite for effective eradication of CSCs. …

… interventions to overcome acquired drug resistance, abrogate tumor progression, and …
malignant tumor microenvironment which have been targeted for effective anticancer therapy and …