… AZD4547 showed strong TAM abolishment and tumor regression, making this receptor a
potential therapeutic target [102]. In addition, targeting other important molecules for monocyte/…

… Expert opinion: The tumor microenvironment is increasingly being viewed as a potential
therapeutic target with a number of strategies being developed to disrupt tumor–stroma …

… A total number of 1,200 papers were scanned for this review with the key words “tumor
microenvironment” and “cancer.” Among them, only about 160 papers were fitted the criteria for …

… into effective therapy targets. In what follows we will review the studies in which these
microenvironmental alterations have been leveraged toward targeted cancer therapy, as well as …

… growth; rather it is a constantly evolving participant in overall tumor growth and fate. This …
in drug therapies and delivery systems targeting hypoxia in the tumor microenvironment. In the …

… Extensive efforts have been devoted to the investigation of CAFs as a potential therapeutic
target. The first strategy is to regulate the formation of CAFs. Myofibroblasts, modulated …

… Finally, emerging approaches in response to tumor hypoxia are presented, with special
emphasis on delivering oxygen, generating oxygen, and targeting tumor hypoxia. …

… a comprehensive analysis of the current therapies targeting the TME and their clinical …
prevalent in the TME and the therapeutics targeting those mechanisms from a preclinical and …

… and diagnostic agents into tumors. Today, it is well accepted that cells at the tumor
microenvironment (TME) contribute in many ways to cancer development and progression. Tumor-…

… Developing novel therapies targeting and normalizing tumor angiogenesis has evolved into
one of the main focuses for tumor treatment. In normal tissues, the vasculature is quiescent, …