… tumor progression in the tumor microenvironment (TME) (2). According to the similarities
in gene expression patterns and functions between TAMs and traditional M1- and M2-type …

… therapies, several of which are reviewed here. Particular emphasis is placed on targeting
such components of the TME as tumor… (CAFs) overexpressing specific therapy targets such as …

… Thereby, IL-6 has been exploited as therapeutic targets against ovarian cancer. Indeed,
preclinical trails revealed that siltuximab and tocilizumab, anti-IL-6 monoclonal antibodies, …

… Accordingly, anti-angiogenesis may be an affective therapy by specifically targeting tumor
… enhances tumor proliferation and immune-therapy resistance. Thus, targeting tumor cell …

… In this review, we will discuss the role of the tumor microenvironment in the incidence of …
tumor microenvironment is critical for facilitating the identification of new therapeutic targets. …

… While therapeutically targeting the tumor microenvironment is an attractive strategy for the
… how the tumor microenvironment contributes to tumorigenesis, new therapeutic targets and …

… to impact therapeutic outcome to PD-1/PD-L1 targeting … tumor, stroma, and their derivatives
(eg, chemokines and other soluble factors) is crucial to developing novel therapeutic targets …

… Osteoclasts, PTHrP, and RANKL have thus been considered as therapeutic targets.
Targeting osteoclasts with bisphosphonates has been among the first successful strategies …

… Therapeutic targeting of angiogenesis factors, tumor associated fibroblasts, and cell …
focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor-…

… emergence of the M2-polarized phenotype and retarded tumor progression in 4T1/BALB/c-…
, implying that therapies targeting these cytokines are optimal for tumors that are refractory …