… development and to identification of therapeutic targets. It has become increasingly evident
that the cellular context in which malignant cells arise – the tumor microenvironment (TME) – …

… The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has been …

… Tyro3, Axl, and Mark, bias macrophage polarization toward a pro-tumor M2-like phenotype.
These receptors are promising therapeutic targets for tumor-associated macrophages 71 . …

… Canonical gene therapy targeting only tumor cells remains … tumor microenvironment can
be considered as the “regulator” and “target” when designing carriers and choosing therapeutic …

… effects on non-target cells that receive intense attention in cancer immunotherapy. This
review explores the mechanisms of tumor microenvironment reprogramming in immunotherapy …

… therapy resistance from the perspective of tumor cell adaptation to a hypoxic microenvironment…
factor HIF-1 in modifying cancer sensitivity to therapeutic agents. Specifically, it aimed to …

… niche sites exhibit characteristics typical of the tumor microenvironment (TME). The complex
… with the surrounding tumor microenvironment led to increased therapeutic challenges. …

… tumor microenvironment, the tumor stroma is highly dynamic, heterogeneous and commonly
tumor… potential novel approaches for tumor-stroma-based therapeutic targeting, with the aim …

… microenvironment and metastasis. Finally, we introduce recent studies on Gas6/TAM targeting
in cancer therapy, … increase the potential use of Gas6 as a therapeutic target for cancer. …

… With the advance of tumor biology and breakthroughs in drug development and drug delivery
technologies, the days of multimodal therapies targeting the tumor microenvironment for …