Inflammation and cardiovascular disease: from pathogenesis to therapeutic target

E Golia, G Limongelli, F Natale, F Fimiani… - Current atherosclerosis …, 2014 - Springer
… the question of inflammation-guided therapy for cardiovascular risk prevention [44]. The
trial investigated whether statin therapy might affect cardiovascular risk in subjects with LDL …

Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammation

AM Miller, IB McInnes - Current pharmaceutical design, 2011 - ingentaconnect.com
… an increased atherosclerotic risk which cannot be explained by traditional cardiovascular
risk factors alone. Inflammatory pathways are implicated in this increased vascular risk. The …

[HTML][HTML] Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk

AB Goldfine, SE Shoelson - The Journal of clinical …, 2017 - Am Soc Clin Investig
… for weight and other risk factors (17, 18). Furthermore, the magnitude of cardiovascular risk
associated with CRP is similar in magnitude to that of traditional risk factors including systolic …

Recent updates on novel therapeutic targets of cardiovascular diseases

M Afzal - Molecular and Cellular Biochemistry, 2021 - Springer
… in cardiac disorders treatment. The emphasis of this review will be on bringing recent
development in cardiac disorders from the discoveries of drug targets and their ligands. …

NF-κB, A potential therapeutic target in cardiovascular diseases

W Cheng, C Cui, G Liu, C Ye, F Shao… - Cardiovascular Drugs …, 2023 - Springer
… Thus, NF-κB is a potential therapeutic target in the treatment of atherosclerosis and related
CVDs. Several biologics and small molecules as well as peptide/proteins have been shown …

[HTML][HTML] Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk

K Kearney, D Tomlinson, K Smith, R Ajjan - Cardiovascular diabetology, 2017 - Springer
therapies, questioning the safety of this approach. Therefore, to safely control thrombosis risk
… with the fibrin network representing a credible therapeutic target. In the current review, we …

High-density lipoproteins: marker of cardiovascular risk and therapeutic target

PP Toth, MH Davidson - Journal of clinical lipidology, 2010 - Elsevier
… III for very high-risk patients, as HDL-C progressively decreases, risk for cardiovascular
events increases. Is simply driving LDL lower enough to optimize cardiovascular risk reduction? …

Endothelial progenitor cells: therapeutic target for cardiovascular diseases

T Umemura, Y Higashi - Journal of pharmacological sciences, 2008 - jstage.jst.go.jp
… EPCs and cardiovascular risk factors and the … cardiovascular risk factors but also lifestyle
modification, such as aerobic exercise, and smoking cessation and pharmacological therapy (…

[HTML][HTML] Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
… ; Yang et al., 2013), representing a new therapeutic target in the treatment of RA. On the
other hand, cardiovascular risk is also highly related to obesity and RA pathology. Accordingly, …

Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges

E Hu, D Lee - Expert Opinion on Therapeutic Targets, 2005 - Taylor & Francis
… onset and progression of cardiovascular disease, modulation of the Rho/ROCK signalling
pathway is a potential strategy for targeting an array of cardiovascular indications. Two widely …