Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer

GH Li, JF Huang - Bioinformatics, 2014 - academic.oup.com
… indicate that HKDC1 is a novel potential therapeutic target for lung cancer. … therapeutic
targets from heterogeneous data. We suggest that HKDC1 is a novel potential therapeutic target

[HTML][HTML] Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs

S Paliwal, A de Giorgio, D Neil, JB Michel… - Scientific reports, 2020 - nature.com
… As more advanced computational methods with the ability to model complex networks
develop, the value of integrating heterogeneous data sources increases. The most promising …

[HTML][HTML] Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational …

S Blot, D Koulenti, M Akova, M Bassetti, JJ De Waele… - Critical Care, 2014 - Springer
target concentrations in the early phase of sepsis [22]. Despite the generally accepted use
of therapeutic drug monitoring (TDM) in vancomycin therapy and … Besides TDM data, dosing …

[HTML][HTML] … of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target …

MC Costa, C Angelini, M Franzese, C Iside… - Journal of Translational …, 2024 - Springer
… drug target information from the Therapeutic Target Database [… in the signature to each
known gene target of the top 50 drugs. … Starting with the gene targets of the prioritized drugs and …

Predicting therapeutic targets with integration of heterogeneous data sources

YF Dai, YY Wang, XM Zhao - … Conference, PRIB 2013, Nice, France, June …, 2013 - Springer
… In this paper, we present a new framework to predict drug therapeutic targets by integrating
heterogeneous data sources for both drugs and proteins. Specifically, we proposed a novel …

… profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets

R Agarwal, J Narayan, A Bhattacharyya, M Saraswat… - Cancer Genetics, 2017 - Elsevier
… a need to apply them cautiously on data other than TCGA by considering the fact that HCC
data used to predict classifiers were highly heterogeneous and influenced by several varying …

Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

Y Liang, H Zhang, X Song, Q Yang - Seminars in cancer biology, 2020 - Elsevier
… In the clinic, patients with higher CXCR4 expression are associated with shorter disease-free
survival in breast cancer [47,48], indicating a promising therapeutic target for prevention …

[HTML][HTML] Target identification among known drugs by deep learning from heterogeneous networks

X Zeng, S Zhu, W Lu, Z Liu, J Huang, Y Zhou… - Chemical …, 2020 - pubs.rsc.org
… drug–target networks. Heterogeneous data sources provide diverse information and a
multi-view perspective in predicting novel DTIs. Incorporating heterogeneous data can potentially …

Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma

A Huang, X Zhao, XR Yang, FQ Li, XL Zhou, K Wu… - Journal of …, 2017 - Elsevier
… , we analyzed variations with therapeutic potential based on known data, and categorized …
In total, we identified 38.6% (27/70) of the patients harbored potential therapeutic targets (Fig. …

Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets

D Amar, T Hait, S Izraeli, R Shamir - Nucleic acids research, 2015 - academic.oup.com
… We demonstrate how to combine these biomarkers with large-scale interaction, mutation and
drug target data, forming a highly valuable disease summary that suggests novel directions …