Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer
GH Li, JF Huang - Bioinformatics, 2014 - academic.oup.com
… indicate that HKDC1 is a novel potential therapeutic target for lung cancer. … therapeutic
targets from heterogeneous data. We suggest that HKDC1 is a novel potential therapeutic target …
targets from heterogeneous data. We suggest that HKDC1 is a novel potential therapeutic target …
[HTML][HTML] Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs
S Paliwal, A de Giorgio, D Neil, JB Michel… - Scientific reports, 2020 - nature.com
… As more advanced computational methods with the ability to model complex networks
develop, the value of integrating heterogeneous data sources increases. The most promising …
develop, the value of integrating heterogeneous data sources increases. The most promising …
[HTML][HTML] Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational …
… target concentrations in the early phase of sepsis [22]. Despite the generally accepted use
of therapeutic drug monitoring (TDM) in vancomycin therapy and … Besides TDM data, dosing …
of therapeutic drug monitoring (TDM) in vancomycin therapy and … Besides TDM data, dosing …
[HTML][HTML] … of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target …
… drug target information from the Therapeutic Target Database [… in the signature to each
known gene target of the top 50 drugs. … Starting with the gene targets of the prioritized drugs and …
known gene target of the top 50 drugs. … Starting with the gene targets of the prioritized drugs and …
Predicting therapeutic targets with integration of heterogeneous data sources
… In this paper, we present a new framework to predict drug therapeutic targets by integrating
heterogeneous data sources for both drugs and proteins. Specifically, we proposed a novel …
heterogeneous data sources for both drugs and proteins. Specifically, we proposed a novel …
… profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets
R Agarwal, J Narayan, A Bhattacharyya, M Saraswat… - Cancer Genetics, 2017 - Elsevier
… a need to apply them cautiously on data other than TCGA by considering the fact that HCC
data used to predict classifiers were highly heterogeneous and influenced by several varying …
data used to predict classifiers were highly heterogeneous and influenced by several varying …
Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets
… In the clinic, patients with higher CXCR4 expression are associated with shorter disease-free
survival in breast cancer [47,48], indicating a promising therapeutic target for prevention …
survival in breast cancer [47,48], indicating a promising therapeutic target for prevention …
[HTML][HTML] Target identification among known drugs by deep learning from heterogeneous networks
… drug–target networks. Heterogeneous data sources provide diverse information and a
multi-view perspective in predicting novel DTIs. Incorporating heterogeneous data can potentially …
multi-view perspective in predicting novel DTIs. Incorporating heterogeneous data can potentially …
Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma
… , we analyzed variations with therapeutic potential based on known data, and categorized …
In total, we identified 38.6% (27/70) of the patients harbored potential therapeutic targets (Fig. …
In total, we identified 38.6% (27/70) of the patients harbored potential therapeutic targets (Fig. …
Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets
… We demonstrate how to combine these biomarkers with large-scale interaction, mutation and
drug target data, forming a highly valuable disease summary that suggests novel directions …
drug target data, forming a highly valuable disease summary that suggests novel directions …
相关搜索
- potential therapeutic targets
- heterogeneous data sources therapeutic targets
- heterogeneous graphs therapeutic targets
- prediction of novel therapeutic targets
- therapeutic targets in osteoarthritis
- heterogeneous data cancer involvement of genes
- focus on breast cancer therapeutic targets
- target identification heterogeneous networks
- dali study therapeutic targets
- preclinical validation of therapeutic targets
- tensor factorization therapeutic targets
- vancomycin dosing therapeutic targets
- expression profiles therapeutic targets
- metastatic progression therapeutic targets
- critically ill patients therapeutic targets