… Thus, NLRP3 inflammasome is a new therapeutic target for AF. … -1, and IL-1β can be
exploited as new therapeutic targets. Some existing CVD medications have been shown to act via …

… -vascular diseases and metabolic disorders. In conclusion miRNAs are critical regulators
in human diseases, holding the promise of being a new class of therapeutic targets for current …

… future as potential therapeutic targets to treat human diseases ( Table 2 ), as they are
endogenous regulators of cell function. However, to use miRNAs as therapeutic targets, their …

… in the pathogenesis of many human diseases. Thus, targeting … developing therapeutics for
inflammatory and fibrosing diseases… , and as a potential therapeutic target in human diseases. …

… The main advantages of human genetics for validating therapeutic targets are that human
genetics is highly relevant to human disease and can differentiate between cause and …

… of potential intervention for therapeutic benefit. Over the coming decades, there is likely to
be a huge increase in the number of therapies for human diseases that target not the genes …

… While the conventional wisdom is to inject GD2-targeted therapies intravenously, it is
increasingly obvious that compartmental therapy (eg, CSF to reach leptomeningeal disease [LM], …

… MiRNAs may also provide a new strategy for therapeutic interventions. In this … disease
development and their potential as novel biomarkers and therapeutic targets for human diseases. …

… cargos, particularly those related to human diseases. We also outline the disease mechanisms
and the therapeutic potentials of new strategies for treating UPS-associated diseases. …

… the context of various disease settings. We discuss current therapeutic strategies utilizing
agonists and antagonists targeting nucleic acid sensors to treat infectious disease, cancer, and …