… in the inflammatory process, and highlights the pros and possibly cons of chemokine and
chemokine receptor antagonism in the therapeutic approach to several inflammatory diseases. …

… In this review we focus on four inflammatory cytokines—tumor necrosis factor α (TNFα), …
diseases. On the basis of pre-clinical and clinical data, we specifically discuss the therapeutic …

… arthritis (RA) as a prototype of inflammatory disease. … underlying RA and other chronic
inflammatory diseases. … offer the prospect of discovering new therapeutic targets. In this review we …

… that have the potential to become therapeutic targets. These pathways can be modified to
effectively retard the progression of the disease. A number of such new agents, referred to as …

Despite considerable progress elucidating the cellular and molecular events associated
with chronic inflammatory bowel diseases (IBD), the etiology of Crohn’s disease (CD) and …

… in chronic inflammatory diseases … disease and gene knockout mice. This review describes
the classical and novel functions of LTs and their receptors in several inflammatory diseases …

… Curiously, they might be important therapeutic targets for patients with CVD [9-13]. This …
high-density lipoprotein cholesterol are key therapeutic targets implemented to reduce CVD rate [ …

… isoform, offers an attractive clinical opportunity to ameliorate systemic inflammatory diseases.
Therapeutic interventions to regulate intracellular HMGB1 biology must still await a deeper …

… and as therapeutic targets in disease. Areas covered: This review discusses the potential
of cysteine cathepsins as therapeutic targets in inflammation-associated diseases and recent …

The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …