… to sites of inflammation is a crucial step in the pathogenesis of acute and chronic forms of
inflammatory diseases including hypersensitivity reactions, autoimmune diseases and ischemia…

… , inflammatory lung diseases, obesity, … therapeutic targets through which impaired phagocytosis
of apoptotic cells and the consequent inflammation could be influenced in these diseases…

… inflammation. This article analyzes the value of HMGB-1 as a therapeutic target for the
treatment of diverse infectious and inflammatory disorders and its interest for human clinical trials. …

… therapeutic target as they help orchestrate the inflammatory infiltrate. Current anti-inflammatory
therapies target immune cells in an attempt to inhibit the production of pro-inflammatory …

The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α and
PPAR-δ, are nuclear receptors that have been the focus of extensive research during the …

… Inhibiting this response is a therefore a promising therapeutic target. T cells use integrins in
essentially all of their functions. They use integrins to migrate in and out of lymph nodes and, …

Atherosclerosis, the main pathophysiological condition leading to cardiovascular disease (CVD),
is now considered to be a chronic inflammatory condition. Statins are the most widely …

… In this regard, alpha7 nicotinic receptors appear to play a major role and may thus represent
potential therapeutic targets for many diseases that have a strong inflammatory component. …

… be a therapeutic target in human suffering from inflammatory bowel disease. An open-label
trial of the PPAR-γ ligand rosiglitazone for the treatment of active ulcerative colitis despite …

… of chronic inflammation Although the etiology of most chronic inflammatory diseases
remains unknown, the initiation of the certain types of chronic inflammation is associated with …