… In this regard, alpha7 nicotinic receptors appear to play a major role and may thus represent
potential therapeutic targets for many diseases that have a strong inflammatory component. …

… different inflammatory and autoimmune diseases, the leukocyte adhesion cascade in general,
and leukocyte integrins in particular, represent key therapeutic targets. … therapeutic targets. …

… of chronic inflammation Although the etiology of most chronic inflammatory diseases
remains unknown, the initiation of the certain types of chronic inflammation is associated with …

Atherosclerosis, the main pathophysiological condition leading to cardiovascular disease (CVD),
is now considered to be a chronic inflammatory condition. Statins are the most widely …

… As a consequence, they have been deeply studied, and the idea to exploit them as therapeutic
targets has focused the interest of experts of different research areas from inflammation to …

Inflammation is a fundamental response to tissue injury and invasion of pathogens, but it is
detrimental in clinically important inflammatory disorders. Leukocytes are key players in the …

… Thus, direct IL-23 blockade may be key in treating some inflammatory autoimmune diseases
… inflammatory disease mediation, and inhibition of their actions may have clinical therapeutic …

… disease … therapeutic targets in inflammatory and fibrotic diseases. Activin antagonists such
as follistatin, an endogenous activin-binding protein, offer considerable promise as therapies …

… Sustained production of IP-10 during autoimmune renal disease may contribute to the …
therapeutic target to prevent the loss of renal function after the acute inflammatory response …

… The therapeutic effect of these neuropeptides is associated with a striking reduction in the
two deleterious components of these diseases: autoimmune and inflammatory responses. …