Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets
P Vihinen, VM Kähäri - International journal of cancer, 2002 - Wiley Online Library
… In addition, therapeutic … trials in cancer. In this review, we discuss the current view on the
feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer. …
feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer. …
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
E Hadler-Olsen, JO Winberg, L Uhlin-Hansen - Tumor Biology, 2013 - Springer
… cancers, there are increased levels of one or several members of the matrix metalloproteinases
… This is a family of proteolytic enzymes that are involved in many phases of cancer …
… This is a family of proteolytic enzymes that are involved in many phases of cancer …
Matrix metalloproteinases as therapeutic targets in cancer
P Vihinen, R Ala-aho, VM Kahari - Current cancer drug targets, 2005 - ingentaconnect.com
… of MMPs as targets for therapeutic intervention in cancer. … Matrix metalloproteinases (MMPs)
are a family of structurally … essentially all components of extracellular matrix (ECM). MMPs …
are a family of structurally … essentially all components of extracellular matrix (ECM). MMPs …
Strategies to target matrix metalloproteinases as therapeutic approach in cancer
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
capable of degrading numerous extracellular matrix (ECM) components thus participating in …
capable of degrading numerous extracellular matrix (ECM) components thus participating in …
[PDF][PDF] Matrix metalloproteinases: new targets in cancer therapy
A Khalid, MA Javaid - J Cancer Sci Ther, 2016 - researchgate.net
Matrix metalloproteinases (MMPs), the entities responsible for eradicating the structure of
extracellular matrix-ECM, are the zinc or calcium ion-dependent enzymes. This family of …
extracellular matrix-ECM, are the zinc or calcium ion-dependent enzymes. This family of …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
… cancer progression and metastasis (4–6). These proteases would seem to offer an obvious
therapeutic target, … progression-free survival of metastatic breast cancer patients (7). Recent …
therapeutic target, … progression-free survival of metastatic breast cancer patients (7). Recent …
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
CM Overall, O Kleifeld - Nature Reviews Cancer, 2006 - nature.com
… However, biovariability between individuals and within an individual is a significant problem
in target validation. Expression levels of candidate therapeutic targets might change in …
in target validation. Expression levels of candidate therapeutic targets might change in …
[HTML][HTML] Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
… matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix … therapeutic and diagnostic targets for the treatment and detection of human …
extracellular matrix … therapeutic and diagnostic targets for the treatment and detection of human …
Matrix metalloproteinases in cancer: prognostic markers and targets for therapy
MJ Duffy, K McCarthy - International journal of oncology, 1998 - spandidos-publications.com
… use of matrix metalloproteinase inhibitors for the treatment of cancer. Eur J Cancer 32A:
2528-2533, 1996. 19. Hua J and Muschel RJ: Inhibition of matrix metalloproteinase 9 expression …
2528-2533, 1996. 19. Hua J and Muschel RJ: Inhibition of matrix metalloproteinase 9 expression …
[HTML][HTML] Matrix metalloproteinases as therapeutic targets in breast cancer
MJ Kwon - Frontiers in Oncology, 2023 - frontiersin.org
… MMP-13 is associated with breast cancer-induced osteolysis, suggesting that MMP-13 is a
promising therapeutic target for breast cancer bone metastasis (88, 89). MMP-13 expression …
promising therapeutic target for breast cancer bone metastasis (88, 89). MMP-13 expression …
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