… In addition, therapeutic … trials in cancer. In this review, we discuss the current view on the
feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer. …

… cancers, there are increased levels of one or several members of the matrix metalloproteinases
… This is a family of proteolytic enzymes that are involved in many phases of cancer …

… of MMPs as targets for therapeutic intervention in cancer. … Matrix metalloproteinases (MMPs)
are a family of structurally … essentially all components of extracellular matrix (ECM). MMPs …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
capable of degrading numerous extracellular matrix (ECM) components thus participating in …

Matrix metalloproteinases (MMPs), the entities responsible for eradicating the structure of
extracellular matrix-ECM, are the zinc or calcium ion-dependent enzymes. This family of …

… cancer progression and metastasis (4–6). These proteases would seem to offer an obvious
therapeutic target, … progression-free survival of metastatic breast cancer patients (7). Recent …

… However, biovariability between individuals and within an individual is a significant problem
in target validation. Expression levels of candidate therapeutic targets might change in …

… matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix … therapeutic and diagnostic targets for the treatment and detection of human …

… use of matrix metalloproteinase inhibitors for the treatment of cancer. Eur J Cancer 32A:
2528-2533, 1996. 19. Hua J and Muschel RJ: Inhibition of matrix metalloproteinase 9 expression …

… MMP-13 is associated with breast cancer-induced osteolysis, suggesting that MMP-13 is a
promising therapeutic target for breast cancer bone metastasis (88, 89). MMP-13 expression …